Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2214544..2215150 Replicon chromosome
Accession NZ_CP040640
Organism Agrobacterium sp. T29

Toxin (Protein)


Gene name PumA Uniprot ID A0A1S7PGV8
Locus tag FGF54_RS11250 Protein ID WP_035263680.1
Coordinates 2214544..2214840 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2L2LE70
Locus tag FGF54_RS11255 Protein ID WP_065655553.1
Coordinates 2214845..2215150 (+) Length 102 a.a.

Genomic Context

FGF54_RS11225FGF54_RS11230FGF54_RS11235FGF54_RS11245FGF54_RS11250FGF54_RS11255FGF54_RS11270FGF54_RS11220FGF54_RS11260FGF54_RS11265FGF54_RS11275
Location: 2211563..2211910 (348 bp)
Type: Others
Protein ID: WP_003522597.1
Location: 2211920..2212444 (525 bp)
Type: Others
Protein ID: WP_142779692.1
Location: 2212621..2213397 (777 bp)
Type: Others
Protein ID: WP_059754584.1
Location: 2213615..2214499 (885 bp)
Type: Others
Protein ID: WP_142779693.1
Location: 2214544..2214840 (297 bp)
Type: Toxin
Protein ID: WP_035263680.1
Location: 2214845..2215150 (306 bp)
Type: Antitoxin
Protein ID: WP_065655553.1
Location: 2217306..2218385 (1080 bp)
Type: Others
Protein ID: WP_142779695.1
Location: 2210482..2211375 (894 bp)
Type: Others
Protein ID: WP_125145461.1
Location: 2215164..2216558 (1395 bp)
Type: Others
Protein ID: WP_142779694.1
Location: 2216555..2217235 (681 bp)
Type: Others
Protein ID: WP_003491888.1
Location: 2218398..2219366 (969 bp)
Type: Others
Protein ID: WP_142779696.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FGF54_RS112202210482..2211375-894WP_125145461.1hemin ABC transporter substrate-binding protein-
FGF54_RS112252211563..2211910+348WP_003522597.1antibiotic biosynthesis monooxygenase-
FGF54_RS112302211920..2212444+525WP_142779692.1heme utilization cystosolic carrier protein HutX-
FGF54_RS112352212621..2213397+777WP_059754584.1YbaY family lipoprotein-
FGF54_RS112452213615..2214499+885WP_142779693.1formyltetrahydrofolate deformylase-
FGF54_RS112502214544..2214840+297WP_035263680.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FGF54_RS112552214845..2215150+306WP_065655553.1putative addiction module antidote proteinAntitoxin
FGF54_RS112602215164..2216558-1395WP_142779694.1sensor histidine kinase-
FGF54_RS112652216555..2217235-681WP_003491888.1response regulator transcription factor-
FGF54_RS112702217306..2218385+1080WP_142779695.1ABC transporter substrate-binding protein-
FGF54_RS112752218398..2219366-969WP_142779696.1alpha/beta fold hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10878.57 Da        Isoelectric Point: 10.2733

>T126239 WP_035263680.1 NZ_CP040640:2214544-2214840 [Agrobacterium sp. T29]
MLTIRETSEFADWLAGLRDVQARARIARRIYRLADGNPGDVKPVGEGVSELRIDLGPGYRVYFVRHGDVVIILLCGGDKA
SQSRDIARAKKLARALKE

Download         Length: 297 bp

>T126239 NZ_CP040640:2214544-2214840 [Agrobacterium sp. T29]
ATGCTCACGATCCGGGAAACAAGCGAGTTTGCCGACTGGCTGGCGGGTCTGCGCGATGTGCAGGCGCGCGCCCGCATAGC
ACGGCGCATTTACCGGCTGGCGGACGGCAATCCCGGAGACGTGAAACCGGTTGGCGAAGGCGTCAGCGAACTCAGGATAG
ACCTTGGACCCGGATATCGGGTCTATTTTGTCCGGCACGGCGATGTCGTCATCATATTGCTGTGTGGCGGCGACAAGGCA
TCGCAGTCCCGCGACATCGCCAGAGCCAAGAAACTGGCCAGAGCGCTCAAGGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10552.83 Da        Isoelectric Point: 4.5437

>AT126239 WP_065655553.1 NZ_CP040640:2214845-2215150 [Agrobacterium sp. T29]
MPLVTRDYDAARYLDSDEALAAYIADATESGDAQELAHALGVVARAKGMTDLSRQTGLPRQTLYKALSGDGNPELATIAK
VADALGYRLSLVAKSPADTAA

Download         Length: 306 bp

>AT126239 NZ_CP040640:2214845-2215150 [Agrobacterium sp. T29]
ATGCCACTTGTGACACGCGATTACGATGCTGCCCGCTACCTTGATAGTGACGAAGCGCTTGCCGCTTACATCGCCGACGC
CACAGAAAGCGGCGACGCACAGGAGCTTGCCCATGCGCTGGGCGTCGTGGCGCGGGCCAAGGGTATGACTGACCTTTCGA
GGCAAACTGGCCTTCCCCGCCAGACCTTGTACAAGGCCCTGAGCGGCGACGGAAATCCGGAACTGGCGACGATTGCCAAG
GTCGCCGACGCGCTGGGCTACAGGCTCTCGCTGGTGGCGAAATCGCCTGCAGACACAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1S7PGV8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2L2LE70

References