126239

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2214544..2215150 Replicon chromosome
Accession NZ_CP040640
Organism Agrobacterium sp. T29

Toxin (Protein)


Gene name PumA Uniprot ID A0A1S7PGV8
Locus tag FGF54_RS11250 Protein ID WP_035263680.1
Coordinates 2214544..2214840 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2L2LE70
Locus tag FGF54_RS11255 Protein ID WP_065655553.1
Coordinates 2214845..2215150 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGF54_RS11220 2210482..2211375 - 894 WP_125145461.1 hemin ABC transporter substrate-binding protein -
FGF54_RS11225 2211563..2211910 + 348 WP_003522597.1 antibiotic biosynthesis monooxygenase -
FGF54_RS11230 2211920..2212444 + 525 WP_142779692.1 heme utilization cystosolic carrier protein HutX -
FGF54_RS11235 2212621..2213397 + 777 WP_059754584.1 YbaY family lipoprotein -
FGF54_RS11245 2213615..2214499 + 885 WP_142779693.1 formyltetrahydrofolate deformylase -
FGF54_RS11250 2214544..2214840 + 297 WP_035263680.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGF54_RS11255 2214845..2215150 + 306 WP_065655553.1 putative addiction module antidote protein Antitoxin
FGF54_RS11260 2215164..2216558 - 1395 WP_142779694.1 sensor histidine kinase -
FGF54_RS11265 2216555..2217235 - 681 WP_003491888.1 response regulator transcription factor -
FGF54_RS11270 2217306..2218385 + 1080 WP_142779695.1 ABC transporter substrate-binding protein -
FGF54_RS11275 2218398..2219366 - 969 WP_142779696.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10878.57 Da        Isoelectric Point: 10.2733

>T126239 WP_035263680.1 NZ_CP040640:2214544-2214840 [Agrobacterium sp. T29]
MLTIRETSEFADWLAGLRDVQARARIARRIYRLADGNPGDVKPVGEGVSELRIDLGPGYRVYFVRHGDVVIILLCGGDKA
SQSRDIARAKKLARALKE

Download         Length: 297 bp

>T126239 NZ_CP040640:2214544-2214840 [Agrobacterium sp. T29]
ATGCTCACGATCCGGGAAACAAGCGAGTTTGCCGACTGGCTGGCGGGTCTGCGCGATGTGCAGGCGCGCGCCCGCATAGC
ACGGCGCATTTACCGGCTGGCGGACGGCAATCCCGGAGACGTGAAACCGGTTGGCGAAGGCGTCAGCGAACTCAGGATAG
ACCTTGGACCCGGATATCGGGTCTATTTTGTCCGGCACGGCGATGTCGTCATCATATTGCTGTGTGGCGGCGACAAGGCA
TCGCAGTCCCGCGACATCGCCAGAGCCAAGAAACTGGCCAGAGCGCTCAAGGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10552.83 Da        Isoelectric Point: 4.5437

>AT126239 WP_065655553.1 NZ_CP040640:2214845-2215150 [Agrobacterium sp. T29]
MPLVTRDYDAARYLDSDEALAAYIADATESGDAQELAHALGVVARAKGMTDLSRQTGLPRQTLYKALSGDGNPELATIAK
VADALGYRLSLVAKSPADTAA

Download         Length: 306 bp

>AT126239 NZ_CP040640:2214845-2215150 [Agrobacterium sp. T29]
ATGCCACTTGTGACACGCGATTACGATGCTGCCCGCTACCTTGATAGTGACGAAGCGCTTGCCGCTTACATCGCCGACGC
CACAGAAAGCGGCGACGCACAGGAGCTTGCCCATGCGCTGGGCGTCGTGGCGCGGGCCAAGGGTATGACTGACCTTTCGA
GGCAAACTGGCCTTCCCCGCCAGACCTTGTACAAGGCCCTGAGCGGCGACGGAAATCCGGAACTGGCGACGATTGCCAAG
GTCGCCGACGCGCTGGGCTACAGGCTCTCGCTGGTGGCGAAATCGCCTGCAGACACAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S7PGV8

Antitoxin

Source ID Structure
AlphaFold DB A0A2L2LE70

References