Detailed information of TA system TA126238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 2039187..2039774
• Replicon: chromosome
• Accession: NZ_CP040640
• Organism: Agrobacterium sp. T29

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FGF54_RS10325
• Protein ID: WP_035260940.1
• Coordinates: 2039187..2039453 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1S7TRQ6
• Locus tag: FGF54_RS10330
• Protein ID: WP_035260938.1
• Coordinates: 2039523..2039774 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGF54_RS10300	2034639..2035358	+	720	WP_142780200.1	sulfite exporter TauE/SafE family protein	-
FGF54_RS10305	2035438..2036571	+	1134	WP_168208055.1	alpha-hydroxy-acid oxidizing protein	-
FGF54_RS10310	2036776..2037120	-	345	WP_003524247.1	multidrug efflux SMR transporter	-
FGF54_RS10315	2037117..2037701	-	585	WP_142779601.1	TetR/AcrR family transcriptional regulator	-
FGF54_RS10320	2037891..2039183	+	1293	WP_168208129.1	D-alanyl-D-alanine carboxypeptidase	-
FGF54_RS10325	2039187..2039453	-	267	WP_035260940.1	Txe/YoeB family addiction module toxin	Toxin
FGF54_RS10330	2039523..2039774	-	252	WP_035260938.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FGF54_RS10335	2039827..2040576	-	750	WP_142779603.1	metallophosphatase family protein	-
FGF54_RS10340	2040582..2040938	-	357	WP_035260925.1	hydroxyisourate hydrolase	-
FGF54_RS10345	2040935..2041435	-	501	WP_142779604.1	ureidoglycolate lyase	-
FGF54_RS10350	2041439..2041801	-	363	WP_035220083.1	DUF86 domain-containing protein	-
FGF54_RS10355	2041798..2042088	-	291	WP_035220685.1	nucleotidyltransferase family protein	-
FGF54_RS10360	2042142..2042639	-	498	WP_142779605.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
FGF54_RS10365	2042639..2043562	-	924	WP_142780201.1	allantoinase PuuE	-
FGF54_RS10370	2043767..2044474	-	708	WP_003524263.1	DUF1045 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10870.49 Da
• Isoelectric Point: 9.0866

>T126238 WP_035260940.1 NZ_CP040640:c2039453-2039187 [Agrobacterium sp. T29]
IALGWSHQGWEDYLHWQQYDRKMLERINELIKDCRRHPFEGIGKPEPLRFQLKGLWSRRISQEHRLVYELRGEAEKTVLI
IHQCRFHY

Nucleotide

• Length: 267 bp

>T126238 NZ_CP040640:c2039453-2039187 [Agrobacterium sp. T29]
ATTGCTCTCGGCTGGAGCCATCAGGGCTGGGAAGACTATCTTCACTGGCAGCAATATGATCGCAAGATGCTCGAACGCAT
CAATGAACTCATCAAGGATTGTCGACGGCATCCATTTGAAGGGATCGGAAAACCTGAGCCACTGCGTTTTCAGTTGAAGG
GCCTATGGTCACGCAGGATTTCGCAGGAGCATCGGCTTGTCTACGAGTTGCGCGGCGAAGCGGAAAAGACGGTTCTGATC
ATTCACCAGTGCCGTTTCCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9432.65 Da
• Isoelectric Point: 4.5242

>AT126238 WP_035260938.1 NZ_CP040640:c2039774-2039523 [Agrobacterium sp. T29]
MRTVMFSKARESLASLLDEVSQDRVTVEIVRRDKPSAVLIDKDEYEGLMETLHLCSSPENFARLRKSMSDVDAGTFESHD
LID

Nucleotide

• Length: 252 bp

>AT126238 NZ_CP040640:c2039774-2039523 [Agrobacterium sp. T29]
ATGCGTACCGTTATGTTTTCGAAAGCACGCGAATCCCTTGCATCGCTTCTGGATGAAGTGTCGCAGGACCGGGTGACTGT
GGAAATCGTGCGCCGCGACAAGCCGTCCGCCGTTCTTATCGACAAGGACGAGTATGAAGGCTTGATGGAAACCTTGCATC
TCTGCTCGTCGCCGGAGAATTTCGCCAGACTTAGAAAGTCGATGTCCGATGTGGACGCGGGTACTTTCGAAAGTCATGAT
CTTATCGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S7TRQ6