Detailed information of TA system TA126237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 794481..795112
• Replicon: chromosome
• Accession: NZ_CP040640
• Organism: Agrobacterium sp. T29

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FGF54_RS04110
• Protein ID: WP_142778994.1
• Coordinates: 794714..795112 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A420GCG3
• Locus tag: FGF54_RS04105
• Protein ID: WP_031233980.1
• Coordinates: 794481..794714 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGF54_RS04080	789951..791213	+	1263	WP_142778992.1	beta-ketoacyl-ACP synthase II	-
FGF54_RS04090	791543..792763	+	1221	WP_142778993.1	endolytic transglycosylase MltG	-
FGF54_RS04095	792832..793719	+	888	WP_003520732.1	YicC family protein	-
FGF54_RS04100	793725..794387	+	663	WP_003502089.1	guanylate kinase	-
FGF54_RS04105	794481..794714	+	234	WP_031233980.1	antitoxin	Antitoxin
FGF54_RS04110	794714..795112	+	399	WP_142778994.1	type II toxin-antitoxin system VapC family toxin	Toxin
FGF54_RS04115	795145..795795	-	651	WP_142778995.1	alpha/beta hydrolase	-
FGF54_RS04120	795869..796699	-	831	WP_142778996.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
FGF54_RS04125	796699..797721	-	1023	WP_142778997.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-
FGF54_RS04130	797748..798695	-	948	WP_003520739.1	peptidylprolyl isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14866.16 Da
• Isoelectric Point: 6.7038

>T126237 WP_142778994.1 NZ_CP040640:794714-795112 [Agrobacterium sp. T29]
MLTYMLDTNICIYVMKTYPPELREKFNALADQLCISSITLGELYYGAEKSIRRQENINAIENFTARLDVLPFADKGAAHY
GQIRAELAKAGTPCGVHDMQIGGHARSEGLIVVTNNMREFVRMPGLRVENWV

Nucleotide

• Length: 399 bp

>T126237 NZ_CP040640:794714-795112 [Agrobacterium sp. T29]
ATGCTTACATATATGCTCGATACCAACATATGTATCTATGTGATGAAGACTTATCCTCCGGAGCTGCGGGAGAAATTCAA
CGCTCTGGCAGATCAACTGTGTATTTCGAGCATCACACTTGGCGAGCTTTATTATGGTGCTGAAAAATCCATCCGGCGCC
AGGAAAACATCAACGCCATTGAAAATTTTACTGCGCGTTTGGACGTTCTGCCTTTCGCCGACAAAGGCGCCGCACATTAC
GGACAGATCAGGGCCGAACTTGCCAAGGCTGGAACGCCATGCGGCGTTCATGATATGCAGATTGGTGGTCACGCCCGTAG
CGAGGGGCTGATCGTCGTAACCAATAATATGCGCGAGTTTGTCCGGATGCCCGGTTTGCGAGTTGAAAACTGGGTTTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8649.92 Da
• Isoelectric Point: 5.7974

>AT126237 WP_031233980.1 NZ_CP040640:794481-794714 [Agrobacterium sp. T29]
MATSTVFISNRSQAVRLPKAVAFPDDVHKVDVLKIGLARVIVPQGKRWDDLFLTGPRATDDFLSVREEPALDEREPF

Nucleotide

• Length: 234 bp

>AT126237 NZ_CP040640:794481-794714 [Agrobacterium sp. T29]
ATGGCTACGTCAACGGTTTTTATAAGCAATCGCAGTCAAGCTGTAAGGCTACCGAAGGCCGTGGCTTTTCCTGATGACGT
GCATAAGGTCGATGTTCTGAAAATCGGTCTCGCGCGTGTTATAGTGCCGCAGGGAAAGCGCTGGGACGACCTTTTTCTGA
CCGGCCCACGTGCAACGGATGATTTTCTTTCCGTTCGCGAAGAGCCTGCATTGGATGAGCGCGAGCCCTTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A420GCG3