Detailed information of TA system TA126233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 364598..365084
• Replicon: chromosome
• Accession: NZ_CP040640
• Organism: Agrobacterium sp. T29

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: FGF54_RS01790
• Protein ID: WP_142778760.1
• Coordinates: 364598..364867 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A822V377
• Locus tag: FGF54_RS01795
• Protein ID: WP_003503188.1
• Coordinates: 364851..365084 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGF54_RS01755	359777..360406	+	630	WP_142778755.1	DNA-3-methyladenine glycosylase I	-
FGF54_RS01760	360403..360846	+	444	WP_142778756.1	hypothetical protein	-
FGF54_RS01765	360862..361905	-	1044	WP_142778757.1	YeiH family protein	-
FGF54_RS01770	361987..362904	+	918	WP_020812649.1	LysR family transcriptional regulator	-
FGF54_RS01775	362957..363331	-	375	WP_142778758.1	DUF305 domain-containing protein	-
FGF54_RS01785	363827..364591	-	765	WP_142778759.1	hypothetical protein	-
FGF54_RS01790	364598..364867	-	270	WP_142778760.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FGF54_RS01795	364851..365084	-	234	WP_003503188.1	ribbon-helix-helix protein, CopG family	Antitoxin
FGF54_RS01800	365242..366762	+	1521	WP_142778761.1	histidine--tRNA ligase	-
FGF54_RS01805	366931..368058	+	1128	WP_142778762.1	ATP phosphoribosyltransferase regulatory subunit	-
FGF54_RS01810	368055..368747	+	693	WP_142778763.1	ATP phosphoribosyltransferase	-
FGF54_RS01815	368815..369261	-	447	WP_142778764.1	DoxX family protein	-
FGF54_RS01820	369413..369847	-	435	WP_142778765.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (6-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10415.94 Da
• Isoelectric Point: 10.0404

>T126233 WP_142778760.1 NZ_CP040640:c364867-364598 [Agrobacterium sp. T29]
MTWRIEFQRAAVKQLGKLTKSDANRIVSFLADRIAEDDNPRRTGAALQGSELGNFWRYRVGDYRIICDIQDHKLVVLVVE
IGHRREIYR

Nucleotide

• Length: 270 bp

>T126233 NZ_CP040640:c364867-364598 [Agrobacterium sp. T29]
TTGACCTGGAGAATTGAATTCCAGCGGGCTGCCGTCAAACAGCTGGGCAAGTTGACGAAGAGCGACGCCAATCGCATCGT
TTCCTTTCTGGCAGACCGGATTGCCGAAGATGACAATCCCCGCAGAACCGGCGCCGCCCTGCAAGGCTCCGAACTCGGAA
ATTTCTGGCGCTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGATCACAAGCTCGTCGTGCTGGTGGTCGAA
ATCGGCCATCGCCGTGAAATCTACCGTTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9212.31 Da
• Isoelectric Point: 4.6044

>AT126233 WP_003503188.1 NZ_CP040640:c365084-364851 [Agrobacterium sp. T29]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEATRQRIANKERTYTLEEVMRDLDLEN

Nucleotide

• Length: 234 bp

>AT126233 NZ_CP040640:c365084-364851 [Agrobacterium sp. T29]
ATGAGCAAACAGACGGCCATACGCCTGCCGGACGAGACCTATGAGCGGCTGAAGGCGCTGTCCGAGCGCACCGGCCGTAC
ATCCGCCTATTACATCCGCGAGGCGATCGAGAAACATATCGAGGATATGGAAGATCTCTATCTTGCCGAAGAGGCGACGC
GGCAGCGCATCGCCAACAAGGAGCGCACCTATACTCTGGAAGAAGTGATGCGCGATCTTGACCTGGAGAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A822V377