Detailed information of TA system TA126227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 542778..543418
• Replicon: chromosome
• Accession: NZ_CP040634
• Organism: Acidipropionibacterium acidipropionici strain FAM 19036

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FEZ30_RS02460
• Protein ID: WP_138572864.1
• Coordinates: 542778..543170 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K7S7C8
• Locus tag: FEZ30_RS02465
• Protein ID: WP_015071399.1
• Coordinates: 543167..543418 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEZ30_RS02440	539015..539278	-	264	WP_062819383.1	metal-sensitive transcriptional regulator	-
FEZ30_RS02445	539457..540158	+	702	WP_071001097.1	DUF3151 family protein	-
FEZ30_RS02450	540219..541085	+	867	WP_015071402.1	GNAT family N-acetyltransferase	-
FEZ30_RS02455	541290..542576	+	1287	WP_015071401.1	adenylosuccinate synthase	-
FEZ30_RS02460	542778..543170	-	393	WP_138572864.1	type II toxin-antitoxin system VapC family toxin	Toxin
FEZ30_RS02465	543167..543418	-	252	WP_015071399.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FEZ30_RS02470	543633..544952	+	1320	WP_062820686.1	phosphoribosylamine--glycine ligase	-
FEZ30_RS02475	545001..546434	+	1434	WP_138572866.1	adenylosuccinate lyase	-
FEZ30_RS02480	546537..547469	-	933	WP_028700703.1	hydrogen peroxide-inducible genes activator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13602.36 Da
• Isoelectric Point: 3.9588

>T126227 WP_138572864.1 NZ_CP040634:c543170-542778 [Acidipropionibacterium acidipropionici]
MIVDTSALVAVLTGEPDAEHLLDVMIGADRLALSAASLVEASVVLEARAGSEAVADLHALLADLDTEVLPCDETQAITAV
QAWSRFGKGRHPAALNLGDLFSYAAAITQGESLLFKGDDFPQTDIVVADR

Nucleotide

• Length: 393 bp

>T126227 NZ_CP040634:c543170-542778 [Acidipropionibacterium acidipropionici]
ATGATCGTCGACACGTCTGCCCTGGTGGCCGTACTCACAGGAGAGCCCGACGCCGAGCACCTGCTTGACGTCATGATCGG
CGCCGACCGCCTGGCATTGAGCGCCGCCAGCCTGGTTGAGGCTTCTGTCGTTCTCGAGGCACGCGCTGGATCCGAGGCGG
TGGCCGATCTTCACGCGCTACTGGCCGACCTCGACACGGAAGTCCTGCCGTGTGACGAGACCCAGGCGATCACAGCAGTT
CAGGCATGGAGCCGTTTCGGGAAGGGGCGTCACCCTGCTGCGCTGAACCTCGGCGACTTGTTCTCATATGCCGCCGCAAT
TACTCAGGGAGAGTCACTTCTCTTCAAGGGCGACGACTTCCCACAAACCGACATCGTGGTAGCCGATCGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9500.56 Da
• Isoelectric Point: 6.0829

>AT126227 WP_015071399.1 NZ_CP040634:c543418-543167 [Acidipropionibacterium acidipropionici]
MALNIKDPDTDRLARELAEETGETLTSALHAALAERLTRVRRQHRVSSRPDLHHYIERARARAVLDDRDADEIIGYDENG
LPR

Nucleotide

• Length: 252 bp

>AT126227 NZ_CP040634:c543418-543167 [Acidipropionibacterium acidipropionici]
ATGGCGCTCAACATCAAGGACCCGGACACCGACCGGCTGGCCCGTGAACTTGCAGAGGAGACCGGCGAGACCCTCACCTC
TGCGCTGCACGCCGCCCTGGCTGAACGCTTGACACGAGTGCGCCGTCAGCACCGGGTCTCCTCCCGGCCCGATCTGCATC
ACTACATCGAACGCGCGCGAGCCAGGGCCGTGCTCGATGATCGCGACGCCGACGAGATCATCGGCTATGACGAGAACGGC
CTGCCACGATGA

Structures

Antitoxin

• AlphaFold DB: K7S7C8