Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 920157..920662 Replicon chromosome
Accession NZ_CP040625
Organism Staphylococcus aureus strain JKD6004-DR

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6E6D5
Locus tag FF960_RS04590 Protein ID WP_001103946.1
Coordinates 920369..920662 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag FF960_RS04585 Protein ID WP_001058492.1
Coordinates 920157..920366 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF960_RS04550 915674..916894 - 1221 WP_000264182.1 site-specific integrase -
FF960_RS04555 916982..917710 - 729 WP_000733773.1 staphylococcal enterotoxin type K -
FF960_RS04560 917734..918462 - 729 WP_001033317.1 staphylococcal enterotoxin type Q -
FF960_RS04565 918637..919371 - 735 WP_000142630.1 helix-turn-helix domain-containing protein -
FF960_RS04570 919521..919733 + 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
FF960_RS04575 919734..920006 + 273 WP_001138298.1 helix-turn-helix domain-containing protein -
FF960_RS04580 920018..920164 + 147 WP_000784885.1 hypothetical protein -
FF960_RS04585 920157..920366 + 210 WP_001058492.1 hypothetical protein Antitoxin
FF960_RS04590 920369..920662 + 294 WP_001103946.1 DUF1474 family protein Toxin
FF960_RS04595 920750..921619 + 870 WP_001002692.1 primase alpha helix C-terminal domain-containing protein -
FF960_RS04600 921636..923093 + 1458 WP_000432707.1 virulence-associated E family protein -
FF960_RS04605 923395..923757 + 363 WP_001039172.1 hypothetical protein -
FF960_RS04610 923759..924043 + 285 WP_000998180.1 hypothetical protein -
FF960_RS04615 924040..924681 + 642 WP_001019783.1 hypothetical protein -
FF960_RS04620 925130..925471 + 342 WP_001190616.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage ant(9)-Ia / erm(A) vWbp / selk / selq 866564..927785 61221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11590.08 Da        Isoelectric Point: 4.9594

>T126208 WP_001103946.1 NZ_CP040625:920369-920662 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Download         Length: 294 bp

>T126208 NZ_CP040625:920369-920662 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGACCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT126208 WP_001058492.1 NZ_CP040625:920157-920366 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT126208 NZ_CP040625:920157-920366 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E6D5

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References