Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 896353..896830 Replicon chromosome
Accession NZ_CP040625
Organism Staphylococcus aureus strain JKD6004-DR

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag FF960_RS04405 Protein ID WP_000052078.1
Coordinates 896353..896541 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FF960_RS04410 Protein ID WP_001059690.1
Coordinates 896570..896830 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF960_RS04375 892394..892864 + 471 WP_000824472.1 hypothetical protein -
FF960_RS04380 893205..893891 + 687 WP_001548082.1 thermonuclease family protein -
FF960_RS04385 894248..894448 + 201 WP_001059082.1 cold-shock protein -
FF960_RS04390 894944..895162 - 219 WP_000005877.1 hypothetical protein -
FF960_RS04395 895224..895508 - 285 WP_001004395.1 hypothetical protein -
FF960_RS04400 895596..896165 - 570 WP_001106654.1 hypothetical protein -
FF960_RS04405 896353..896541 - 189 WP_000052078.1 hypothetical protein Toxin
FF960_RS04410 896570..896830 - 261 WP_001059690.1 hypothetical protein Antitoxin
FF960_RS04415 897171..897374 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FF960_RS04420 897371..897607 - 237 WP_000368687.1 hypothetical protein -
FF960_RS04425 897832..898413 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
FF960_RS04430 898486..899103 - 618 WP_000255564.1 LysE/ArgO family amino acid transporter -
FF960_RS04435 899258..899752 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FF960_RS04440 900151..900573 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FF960_RS04445 900721..901437 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage ant(9)-Ia / erm(A) vWbp / selk / selq 866564..927785 61221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T126207 WP_000052078.1 NZ_CP040625:c896541-896353 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T126207 NZ_CP040625:c896541-896353 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT126207 WP_001059690.1 NZ_CP040625:c896830-896570 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT126207 NZ_CP040625:c896830-896570 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References