Detailed information of TA system TA126198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2141739..2142268
• Replicon: chromosome
• Accession: NZ_CP040623
• Organism: Staphylococcus aureus strain D592-HR

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FF959_RS10875
• Protein ID: WP_000621175.1
• Coordinates: 2141739..2142101 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: FF959_RS10880
• Protein ID: WP_000948331.1
• Coordinates: 2142098..2142268 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF959_RS10855	2138717..2139487	-	771	WP_001041111.1	RNA polymerase sigma factor SigB	-
FF959_RS10860	2139462..2139941	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
FF959_RS10865	2139943..2140269	-	327	WP_001052491.1	anti-sigma factor antagonist	-
FF959_RS10870	2140388..2141389	-	1002	WP_000390827.1	PP2C family protein-serine/threonine phosphatase	-
FF959_RS10875	2141739..2142101	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FF959_RS10880	2142098..2142268	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
FF959_RS10885	2142353..2143501	-	1149	WP_001281154.1	alanine racemase	-
FF959_RS10890	2143567..2143926	-	360	WP_000581197.1	holo-ACP synthase	-
FF959_RS10895	2143930..2144421	-	492	WP_001205912.1	PH domain-containing protein	-
FF959_RS10900	2144408..2145991	-	1584	WP_001294626.1	PH domain-containing protein	-
FF959_RS10905	2145984..2146463	-	480	WP_001287087.1	hypothetical protein	-
FF959_RS10910	2146671..2147231	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T126198 WP_000621175.1 NZ_CP040623:c2142101-2141739 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T126198 NZ_CP040623:c2142101-2141739 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT126198 WP_000948331.1 NZ_CP040623:c2142268-2142098 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT126198 NZ_CP040623:c2142268-2142098 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1