Detailed information of TA system TA126171

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 869207..869739
• Replicon: chromosome
• Accession: NZ_CP040622
• Organism: Staphylococcus aureus strain JKD6004

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: FF958_RS04265
• Protein ID: WP_001103942.1
• Coordinates: 869419..869739 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: FF958_RS04260
• Protein ID: WP_116100508.1
• Coordinates: 869207..869416 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF958_RS04225	865537..866001	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
FF958_RS04235	866564..867670	-	1107	WP_106699245.1	site-specific integrase	-
FF958_RS04240	867660..868463	-	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
FF958_RS04245	868599..868802	+	204	WP_001045296.1	transcriptional regulator	-
FF958_RS04250	868838..869056	+	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
FF958_RS04255	869068..869214	+	147	WP_000784885.1	hypothetical protein	-
FF958_RS04260	869207..869416	+	210	WP_116100508.1	pathogenicity island protein	Antitoxin
FF958_RS04265	869419..869739	+	321	WP_001103942.1	DUF1474 family protein	Toxin
FF958_RS04270	869803..870672	+	870	WP_130826599.1	primase alpha helix C-terminal domain-containing protein	-
FF958_RS04275	870689..872158	+	1470	WP_053040304.1	virulence-associated E family protein	-
FF958_RS04280	872437..872799	+	363	WP_138663888.1	pathogenicity island protein	-
FF958_RS04285	872801..873064	+	264	WP_001804819.1	hypothetical protein	-
FF958_RS04290	873066..873707	+	642	WP_116100509.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	ant(9)-Ia / erm(A)	vWbp / selk / selq	866564..927785	61221

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T126171 WP_001103942.1 NZ_CP040622:869419-869739 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T126171 NZ_CP040622:869419-869739 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8166.22 Da
• Isoelectric Point: 4.4665

>AT126171 WP_116100508.1 NZ_CP040622:869207-869416 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLGKGE

Nucleotide

• Length: 210 bp

>AT126171 NZ_CP040622:869207-869416 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTAGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGGGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4