Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 1943439..1944215 Replicon chromosome
Accession NZ_CP040619
Organism Staphylococcus aureus strain J01

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag FF957_RS09710 Protein ID WP_000031108.1
Coordinates 1943439..1943591 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag FF957_RS09715 Protein ID WP_031806872.1
Coordinates 1943616..1944215 (-) Length 200 a.a.

Genomic Context


FF957_RS09695FF957_RS09700FF957_RS09705FF957_RS09710FF957_RS09715FF957_RS09720FF957_RS09725FF957_RS09730FF957_RS09735
Location: 1939402..1940223 (822 bp)
Type: Others
Protein ID: WP_000669376.1
Location: 1940686..1942071 (1386 bp)
Type: Others
Protein ID: WP_000116224.1
Location: 1942267..1942662 (396 bp)
Type: Others
Protein ID: WP_000901021.1
Location: 1943439..1943591 (153 bp)
Type: Toxin
Protein ID: WP_000031108.1
Location: 1943616..1944215 (600 bp)
Type: Antitoxin
Protein ID: WP_031806872.1
Location: 1944374..1944844 (471 bp)
Type: Others
Protein ID: WP_000181398.1
Location: 1944849..1945976 (1128 bp)
Type: Others
Protein ID: WP_000379978.1
Location: 1946127..1946849 (723 bp)
Type: Others
Protein ID: WP_000590809.1
Location: 1946842..1948299 (1458 bp)
Type: Others
Protein ID: WP_000649907.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FF957_RS096951939402..1940223+822WP_000669376.1RluA family pseudouridine synthase-
FF957_RS097001940686..1942071-1386WP_000116224.1class II fumarate hydratase-
FF957_RS097051942267..1942662-396WP_000901021.1hypothetical protein-
FF957_RS097101943439..1943591-153WP_000031108.1hypothetical proteinToxin
FF957_RS097151943616..1944215-600WP_031806872.1glucosamine-6-phosphate isomeraseAntitoxin
FF957_RS097201944374..1944844-471WP_000181398.1tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL-
FF957_RS097251944849..1945976-1128WP_000379978.1tRNA epoxyqueuosine(34) reductase QueG-
FF957_RS097301946127..1946849-723WP_000590809.1amino acid ABC transporter ATP-binding protein-
FF957_RS097351946842..1948299-1458WP_000649907.1ABC transporter permease subunit-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-196)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T126158 WP_000031108.1 NZ_CP040619:c1943591-1943439 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T126158 NZ_CP040619:c1943591-1943439 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22333.43 Da        Isoelectric Point: 5.1445

>AT126158 WP_031806872.1 NZ_CP040619:c1944215-1943616 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQASVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT126158 NZ_CP040619:c1944215-1943616 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGTCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBX5E2E6


Antitoxin

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Source
ID
Structure
No matching records found

References