Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 853940..854417 Replicon chromosome
Accession NZ_CP040619
Organism Staphylococcus aureus strain J01

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag FF957_RS04205 Protein ID WP_000052078.1
Coordinates 853940..854128 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FF957_RS04210 Protein ID WP_001059690.1
Coordinates 854157..854417 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF957_RS04175 849981..850451 + 471 WP_000824472.1 hypothetical protein -
FF957_RS04180 850792..851478 + 687 WP_001548082.1 thermonuclease family protein -
FF957_RS04185 851835..852035 + 201 WP_001059082.1 cold-shock protein -
FF957_RS04190 852531..852749 - 219 WP_000005886.1 hypothetical protein -
FF957_RS04195 852811..853095 - 285 WP_001004395.1 hypothetical protein -
FF957_RS04200 853183..853752 - 570 WP_001106654.1 hypothetical protein -
FF957_RS04205 853940..854128 - 189 WP_000052078.1 hypothetical protein Toxin
FF957_RS04210 854157..854417 - 261 WP_001059690.1 hypothetical protein Antitoxin
FF957_RS04215 854758..854961 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FF957_RS04220 854958..855194 - 237 WP_000368687.1 hypothetical protein -
FF957_RS04225 855419..856000 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
FF957_RS04230 856073..856690 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FF957_RS04235 856845..857339 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FF957_RS04240 857738..858160 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FF957_RS04245 858308..859024 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T126155 WP_000052078.1 NZ_CP040619:c854128-853940 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T126155 NZ_CP040619:c854128-853940 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT126155 WP_001059690.1 NZ_CP040619:c854417-854157 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT126155 NZ_CP040619:c854417-854157 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References