Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4486468..4487102 Replicon chromosome
Accession NZ_CP040605
Organism Saccharopolyspora sp. ASAGF58

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FDZ84_RS21495 Protein ID WP_168587369.1
Coordinates 4486701..4487102 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FDZ84_RS21490 Protein ID WP_168590247.1
Coordinates 4486468..4486704 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ84_RS21470 4482339..4482917 - 579 WP_168587365.1 DUF3000 domain-containing protein -
FDZ84_RS21475 4483186..4484277 + 1092 WP_168587366.1 uroporphyrinogen decarboxylase -
FDZ84_RS21480 4484277..4485713 + 1437 WP_168587367.1 protoporphyrinogen oxidase -
FDZ84_RS21485 4485718..4486413 + 696 WP_168587368.1 chlorite dismutase family protein -
FDZ84_RS21490 4486468..4486704 + 237 WP_168590247.1 antitoxin Antitoxin
FDZ84_RS21495 4486701..4487102 + 402 WP_168587369.1 PIN domain-containing protein Toxin
FDZ84_RS21500 4487106..4487276 - 171 Protein_4213 peptide-methionine (R)-S-oxide reductase -
FDZ84_RS21505 4487362..4487751 - 390 WP_168587370.1 hypothetical protein -
FDZ84_RS21510 4488252..4488677 - 426 WP_168587371.1 peptide-methionine (R)-S-oxide reductase MsrB -
FDZ84_RS21515 4488723..4489802 - 1080 WP_168587372.1 winged helix DNA-binding domain-containing protein -
FDZ84_RS21520 4489854..4490153 - 300 WP_168587373.1 hypothetical protein -
FDZ84_RS21525 4490544..4491320 + 777 WP_168590248.1 DUF4389 domain-containing protein -
FDZ84_RS21530 4491324..4491866 - 543 WP_168587374.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14436.75 Da        Isoelectric Point: 6.3256

>T126143 WP_168587369.1 NZ_CP040605:4486701-4487102 [Saccharopolyspora sp. ASAGF58]
MSEFVVDASTLVLATTVVSDGAREVRRRLLQSECHAPHLVDAEVGNVLRRQELGGQIEAEAATTALLAMKHLVDHRYPHV
GPLSQAAWELRGVVTFFDALYVALAAGLDVPLLTADARLSRAPKLPCKVELIM

Download         Length: 402 bp

>T126143 NZ_CP040605:4486701-4487102 [Saccharopolyspora sp. ASAGF58]
TTGAGCGAATTCGTCGTTGACGCCTCAACCCTCGTGCTGGCAACCACAGTCGTGTCGGACGGGGCCCGTGAGGTGCGCCG
TCGGCTGCTGCAGAGCGAGTGCCACGCACCGCACCTTGTCGACGCAGAGGTCGGGAACGTGCTTAGAAGGCAGGAATTGG
GCGGGCAGATCGAGGCGGAAGCCGCGACGACTGCGCTCCTCGCGATGAAGCACTTGGTCGACCACCGCTATCCCCACGTA
GGTCCGCTCAGCCAAGCAGCCTGGGAGTTGCGTGGTGTGGTCACGTTCTTTGACGCGCTCTACGTGGCGCTGGCTGCTGG
CCTGGACGTGCCGCTGCTGACAGCCGACGCGAGGCTGTCCCGCGCTCCCAAGCTCCCGTGCAAGGTGGAATTGATCATGT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8675.88 Da        Isoelectric Point: 8.6008

>AT126143 WP_168590247.1 NZ_CP040605:4486468-4486704 [Saccharopolyspora sp. ASAGF58]
MATIQIRDIPEEAYETIRKRARSAGMSLQAYMRDEVVRMASRRTKEEALAAVEAALAHDRGTGVTVESILAAKDADRR

Download         Length: 237 bp

>AT126143 NZ_CP040605:4486468-4486704 [Saccharopolyspora sp. ASAGF58]
ATGGCGACCATTCAGATCCGGGACATCCCGGAAGAGGCGTACGAGACGATCCGCAAACGAGCACGATCCGCTGGGATGTC
GCTGCAGGCGTACATGCGCGATGAAGTCGTGCGCATGGCGTCGCGCCGGACGAAGGAAGAAGCGCTCGCGGCAGTCGAGG
CGGCACTCGCTCACGATCGCGGCACCGGAGTGACCGTCGAGAGCATCCTCGCGGCAAAGGATGCTGATCGGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References