Detailed information of TA system TA126142

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 4474051..4474724
• Replicon: chromosome
• Accession: NZ_CP040605
• Organism: Saccharopolyspora sp. ASAGF58

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FDZ84_RS21435
• Protein ID: WP_168587361.1
• Coordinates: 4474323..4474724 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FDZ84_RS21430
• Protein ID: WP_168587360.1
• Coordinates: 4474051..4474323 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ84_RS21415	4470046..4471986	+	1941	WP_168587357.1	1-deoxy-D-xylulose-5-phosphate synthase	-
FDZ84_RS21420	4472173..4472859	+	687	WP_168587358.1	response regulator transcription factor	-
FDZ84_RS21425	4472864..4474009	+	1146	WP_168587359.1	HAMP domain-containing histidine kinase	-
FDZ84_RS21430	4474051..4474323	+	273	WP_168587360.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FDZ84_RS21435	4474323..4474724	+	402	WP_168587361.1	type II toxin-antitoxin system VapC family toxin	Toxin
FDZ84_RS21440	4474812..4475354	-	543	WP_210435737.1	Uma2 family endonuclease	-
FDZ84_RS21445	4475503..4477668	-	2166	WP_168587363.1	enoyl-CoA hydratase/isomerase family protein	-
FDZ84_RS21450	4477665..4478906	-	1242	WP_210435034.1	acetyl-CoA C-acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14555.74 Da
• Isoelectric Point: 5.9753

>T126142 WP_168587361.1 NZ_CP040605:4474323-4474724 [Saccharopolyspora sp. ASAGF58]
VIYLDSAALIKLVRRERESDALADWLEQQPNVPLVASALVEVEVPRALRRYEPNLLSAVPAVLKRIGVYDIDDVVRATAA
AYQDVLLRSLDAIHLATAHAIFGAHLTAFVTYDHRLHKAAEDVGLPVAQPGTV

Nucleotide

• Length: 402 bp

>T126142 NZ_CP040605:4474323-4474724 [Saccharopolyspora sp. ASAGF58]
GTGATCTACCTCGACAGCGCTGCGCTCATCAAGCTGGTAAGACGGGAACGAGAAAGCGACGCACTGGCGGATTGGTTGGA
GCAACAGCCGAATGTACCGCTGGTCGCATCTGCGCTCGTCGAGGTGGAGGTTCCGCGGGCACTACGACGGTACGAACCGA
ACTTGCTCAGCGCCGTCCCCGCCGTTCTGAAGCGGATCGGCGTCTACGACATTGACGACGTGGTACGAGCTACGGCCGCT
GCGTACCAAGATGTCCTGCTGCGTTCACTCGACGCTATTCACCTTGCGACGGCACATGCGATCTTCGGTGCGCACCTGAC
GGCATTCGTGACCTACGACCATCGTCTCCACAAGGCGGCCGAAGATGTTGGATTGCCAGTCGCACAACCAGGAACGGTTT
GA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9965.45 Da
• Isoelectric Point: 6.2274

>AT126142 WP_168587360.1 NZ_CP040605:4474051-4474323 [Saccharopolyspora sp. ASAGF58]
MSEVSVRMLNQETSSVLARVKHGEEIDITERGAIIARIIPAHPHPLGELIASGKFRPPTLEGAMPRPLGPVRTDVDASAL
IRELRDEERY

Nucleotide

• Length: 273 bp

>AT126142 NZ_CP040605:4474051-4474323 [Saccharopolyspora sp. ASAGF58]
ATGAGCGAGGTGTCGGTCCGCATGCTGAACCAGGAGACGTCGAGCGTCCTGGCCAGAGTCAAACACGGCGAAGAAATCGA
CATCACCGAACGCGGTGCCATCATCGCCAGGATCATTCCTGCGCATCCCCACCCTCTCGGCGAGCTGATCGCTTCTGGGA
AGTTCCGCCCGCCGACTCTGGAGGGGGCGATGCCCCGGCCACTCGGCCCTGTTCGAACTGACGTGGACGCGAGCGCACTC
ATCCGTGAGCTACGAGATGAGGAGCGTTACTAG