Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3792353..3792917 Replicon chromosome
Accession NZ_CP040605
Organism Saccharopolyspora sp. ASAGF58

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FDZ84_RS18140 Protein ID WP_168586884.1
Coordinates 3792353..3792700 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FDZ84_RS18145 Protein ID WP_010696019.1
Coordinates 3792687..3792917 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ84_RS18115 3789150..3789338 + 189 WP_168586880.1 MbtH family protein -
FDZ84_RS18125 3789589..3790683 + 1095 WP_168586881.1 LLM class flavin-dependent oxidoreductase -
FDZ84_RS18130 3791001..3791396 + 396 WP_168586882.1 DUF3817 domain-containing protein -
FDZ84_RS18135 3791396..3792331 + 936 WP_168586883.1 heme o synthase -
FDZ84_RS18140 3792353..3792700 - 348 WP_168586884.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FDZ84_RS18145 3792687..3792917 - 231 WP_010696019.1 ribbon-helix-helix domain-containing protein Antitoxin
FDZ84_RS18150 3793041..3793664 - 624 WP_168586885.1 maleylpyruvate isomerase N-terminal domain-containing protein -
FDZ84_RS18155 3793661..3794395 - 735 WP_168586886.1 PIG-L family deacetylase -
FDZ84_RS18160 3794795..3795346 + 552 Protein_3560 snapalysin family zinc-dependent metalloprotease -
FDZ84_RS18165 3795491..3796759 + 1269 WP_168585803.1 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12604.46 Da        Isoelectric Point: 11.5692

>T126139 WP_168586884.1 NZ_CP040605:c3792700-3792353 [Saccharopolyspora sp. ASAGF58]
MRRGDLYWVDFEPIRGSEANKTRPAVVISNDAANRGAQRAGRGVITVVPVTSNIDRVHPFQVLLRAAECGLPNDSKAQAE
QVRAVAVNRIGNRIGTLPQNTLAKLESALRLHLRL

Download         Length: 348 bp

>T126139 NZ_CP040605:c3792700-3792353 [Saccharopolyspora sp. ASAGF58]
ATGCGCCGCGGTGACCTCTACTGGGTCGACTTCGAACCCATCCGCGGCTCGGAAGCCAACAAGACCCGCCCCGCGGTCGT
CATCAGCAACGACGCCGCGAACCGCGGCGCCCAGCGGGCCGGGCGAGGAGTGATCACCGTCGTGCCGGTGACCTCCAACA
TCGACCGCGTGCACCCGTTCCAGGTGCTCCTGCGGGCCGCCGAATGCGGCCTGCCCAACGACTCGAAAGCCCAGGCCGAG
CAGGTCCGGGCGGTCGCGGTCAACCGCATCGGCAACCGCATCGGAACCTTGCCGCAGAACACCCTCGCCAAGCTCGAGAG
CGCCCTCCGACTCCACCTCCGCCTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8165.86 Da        Isoelectric Point: 3.7671

>AT126139 WP_010696019.1 NZ_CP040605:c3792917-3792687 [Saccharopolyspora sp. ASAGF58]
MKVSVSLTDEDVTFVDEYAQQIGAPSRSAVIHQAINLLRNAGLEDAYASAWEEWDGSADAQLWDATAADGIADAPR

Download         Length: 231 bp

>AT126139 NZ_CP040605:c3792917-3792687 [Saccharopolyspora sp. ASAGF58]
ATGAAGGTGAGTGTGAGCCTGACCGACGAAGACGTCACCTTCGTCGACGAGTACGCCCAGCAGATCGGCGCGCCATCGCG
GTCGGCAGTAATCCATCAGGCGATCAACCTGCTGCGCAACGCCGGCCTGGAAGACGCCTACGCCAGCGCCTGGGAGGAGT
GGGACGGCAGCGCCGACGCGCAACTGTGGGACGCGACTGCCGCCGACGGAATCGCCGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References