Detailed information of TA system TA126139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3792353..3792917
• Replicon: chromosome
• Accession: NZ_CP040605
• Organism: Saccharopolyspora sp. ASAGF58

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FDZ84_RS18140
• Protein ID: WP_168586884.1
• Coordinates: 3792353..3792700 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FDZ84_RS18145
• Protein ID: WP_010696019.1
• Coordinates: 3792687..3792917 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ84_RS18115	3789150..3789338	+	189	WP_168586880.1	MbtH family protein	-
FDZ84_RS18125	3789589..3790683	+	1095	WP_168586881.1	LLM class flavin-dependent oxidoreductase	-
FDZ84_RS18130	3791001..3791396	+	396	WP_168586882.1	DUF3817 domain-containing protein	-
FDZ84_RS18135	3791396..3792331	+	936	WP_168586883.1	heme o synthase	-
FDZ84_RS18140	3792353..3792700	-	348	WP_168586884.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FDZ84_RS18145	3792687..3792917	-	231	WP_010696019.1	ribbon-helix-helix domain-containing protein	Antitoxin
FDZ84_RS18150	3793041..3793664	-	624	WP_168586885.1	maleylpyruvate isomerase N-terminal domain-containing protein	-
FDZ84_RS18155	3793661..3794395	-	735	WP_168586886.1	PIG-L family deacetylase	-
FDZ84_RS18160	3794795..3795346	+	552	Protein_3560	snapalysin family zinc-dependent metalloprotease	-
FDZ84_RS18165	3795491..3796759	+	1269	WP_168585803.1	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12604.46 Da
• Isoelectric Point: 11.5692

>T126139 WP_168586884.1 NZ_CP040605:c3792700-3792353 [Saccharopolyspora sp. ASAGF58]
MRRGDLYWVDFEPIRGSEANKTRPAVVISNDAANRGAQRAGRGVITVVPVTSNIDRVHPFQVLLRAAECGLPNDSKAQAE
QVRAVAVNRIGNRIGTLPQNTLAKLESALRLHLRL

Nucleotide

• Length: 348 bp

>T126139 NZ_CP040605:c3792700-3792353 [Saccharopolyspora sp. ASAGF58]
ATGCGCCGCGGTGACCTCTACTGGGTCGACTTCGAACCCATCCGCGGCTCGGAAGCCAACAAGACCCGCCCCGCGGTCGT
CATCAGCAACGACGCCGCGAACCGCGGCGCCCAGCGGGCCGGGCGAGGAGTGATCACCGTCGTGCCGGTGACCTCCAACA
TCGACCGCGTGCACCCGTTCCAGGTGCTCCTGCGGGCCGCCGAATGCGGCCTGCCCAACGACTCGAAAGCCCAGGCCGAG
CAGGTCCGGGCGGTCGCGGTCAACCGCATCGGCAACCGCATCGGAACCTTGCCGCAGAACACCCTCGCCAAGCTCGAGAG
CGCCCTCCGACTCCACCTCCGCCTATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8165.86 Da
• Isoelectric Point: 3.7671

>AT126139 WP_010696019.1 NZ_CP040605:c3792917-3792687 [Saccharopolyspora sp. ASAGF58]
MKVSVSLTDEDVTFVDEYAQQIGAPSRSAVIHQAINLLRNAGLEDAYASAWEEWDGSADAQLWDATAADGIADAPR

Nucleotide

• Length: 231 bp

>AT126139 NZ_CP040605:c3792917-3792687 [Saccharopolyspora sp. ASAGF58]
ATGAAGGTGAGTGTGAGCCTGACCGACGAAGACGTCACCTTCGTCGACGAGTACGCCCAGCAGATCGGCGCGCCATCGCG
GTCGGCAGTAATCCATCAGGCGATCAACCTGCTGCGCAACGCCGGCCTGGAAGACGCCTACGCCAGCGCCTGGGAGGAGT
GGGACGGCAGCGCCGACGCGCAACTGTGGGACGCGACTGCCGCCGACGGAATCGCCGATGCGCCGCGGTGA