Detailed information of TA system TA126138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1785076..1785599
• Replicon: chromosome
• Accession: NZ_CP040605
• Organism: Saccharopolyspora sp. ASAGF58

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FDZ84_RS08190
• Protein ID: WP_168585397.1
• Coordinates: 1785339..1785599 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FDZ84_RS08185
• Protein ID: WP_168589896.1
• Coordinates: 1785076..1785342 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ84_RS08175	1782401..1784071	-	1671	WP_168589895.1	DNA polymerase Y family protein	-
FDZ84_RS08180	1784074..1784787	-	714	WP_168585396.1	hypothetical protein	-
FDZ84_RS08185	1785076..1785342	+	267	WP_168589896.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FDZ84_RS08190	1785339..1785599	+	261	WP_168585397.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FDZ84_RS08195	1785832..1787397	-	1566	WP_168585398.1	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	-
FDZ84_RS08200	1787394..1788068	-	675	WP_168589897.1	phosphoribosylglycinamide formyltransferase	-
FDZ84_RS08205	1788166..1789638	-	1473	WP_168585399.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (11-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 9.5794

>T126138 WP_168585397.1 NZ_CP040605:1785339-1785599 [Saccharopolyspora sp. ASAGF58]
VTYTIKITARAGRDLACFPEKVASACAEFIFGPLAENPHRLGKPLFGEFKGLHSARRSAYRVVYAIQDDTVVVEVVRIAH
RADVYR

Nucleotide

• Length: 261 bp

>T126138 NZ_CP040605:1785339-1785599 [Saccharopolyspora sp. ASAGF58]
GTGACCTACACGATCAAGATCACCGCACGTGCAGGGCGCGACCTCGCATGCTTCCCGGAGAAGGTCGCATCGGCTTGCGC
CGAGTTCATCTTCGGGCCGCTGGCCGAGAACCCGCACCGGCTCGGCAAACCACTGTTCGGAGAGTTCAAGGGCCTGCACT
CGGCTCGACGGAGCGCGTACCGCGTGGTGTACGCGATTCAAGACGACACCGTGGTGGTCGAAGTCGTCCGGATCGCCCAT
CGAGCCGACGTCTACCGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9659.72 Da
• Isoelectric Point: 4.1851

>AT126138 WP_168589896.1 NZ_CP040605:1785076-1785342 [Saccharopolyspora sp. ASAGF58]
MTTIPLGEARDRLSEVVAQVESTHDRVEITRHGRPAAVLISPDDLSSLEETLDLLTTPGEAEAIREGVADAAAERFVDTE
EIKSRYLQ

Nucleotide

• Length: 267 bp

>AT126138 NZ_CP040605:1785076-1785342 [Saccharopolyspora sp. ASAGF58]
ATGACGACGATCCCATTAGGAGAAGCTCGCGACCGGCTGTCAGAGGTGGTCGCGCAGGTCGAGAGCACCCATGATCGAGT
TGAAATCACCCGGCATGGTCGACCCGCCGCGGTCCTCATCTCCCCCGACGACCTGTCGTCCCTAGAAGAGACCCTGGACC
TACTGACCACTCCCGGCGAGGCGGAGGCCATTCGGGAGGGCGTGGCAGACGCGGCAGCGGAGCGCTTCGTTGACACCGAA
GAAATCAAGAGTCGCTACCTGCAGTGA