Detailed information of TA system TA126137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 1108821..1109485
• Replicon: chromosome
• Accession: NZ_CP040605
• Organism: Saccharopolyspora sp. ASAGF58

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FDZ84_RS04930
• Protein ID: WP_168584913.1
• Coordinates: 1108821..1109216 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FDZ84_RS04935
• Protein ID: WP_168589814.1
• Coordinates: 1109213..1109485 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ84_RS04910	1104990..1105709	+	720	WP_168584909.1	FadR family transcriptional regulator	-
FDZ84_RS04915	1105734..1105982	-	249	WP_168584910.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
FDZ84_RS04920	1106081..1107601	-	1521	WP_168584911.1	cobyric acid synthase	-
FDZ84_RS04925	1107824..1108681	-	858	WP_168584912.1	type I methionyl aminopeptidase	-
FDZ84_RS04930	1108821..1109216	-	396	WP_168584913.1	type II toxin-antitoxin system VapC family toxin	Toxin
FDZ84_RS04935	1109213..1109485	-	273	WP_168589814.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FDZ84_RS04940	1109543..1111366	-	1824	WP_168584914.1	penicillin-binding protein	-
FDZ84_RS04945	1111460..1112296	-	837	WP_168589815.1	GNAT family N-acetyltransferase	-
FDZ84_RS04950	1112493..1113647	-	1155	WP_168584915.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-113)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-41)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14090.13 Da
• Isoelectric Point: 5.1702

>T126137 WP_168584913.1 NZ_CP040605:c1109216-1108821 [Saccharopolyspora sp. ASAGF58]
MIYFDSSALIKLIAPEPESKALSQWIRERWEHPRVTSALSKVDVLRTFREVGPAAEDLASIIVSKIDQLPVKQDVLDVAT
ELRGNVGPVDAIHLASACKIKNGLHAYVSYDPALLAAAEEAGLTTASPGAN

Nucleotide

• Length: 396 bp

>T126137 NZ_CP040605:c1109216-1108821 [Saccharopolyspora sp. ASAGF58]
TTGATCTATTTCGATTCCTCCGCGCTGATCAAGTTGATCGCCCCCGAGCCGGAGAGCAAGGCGCTGAGCCAATGGATCCG
CGAGCGCTGGGAACACCCCCGCGTGACCAGCGCGTTGTCGAAGGTCGACGTGCTGCGCACCTTCCGTGAGGTAGGGCCGG
CCGCCGAAGACCTGGCGTCGATCATCGTGTCGAAGATCGACCAGCTGCCGGTGAAGCAGGACGTGCTCGACGTGGCCACC
GAGCTGCGTGGCAACGTCGGCCCGGTGGACGCCATCCACCTGGCCTCCGCGTGCAAGATCAAGAACGGTCTGCATGCCTA
CGTCTCGTACGATCCGGCGCTACTGGCTGCGGCGGAAGAAGCAGGGCTGACCACGGCCTCACCAGGCGCGAACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10022.38 Da
• Isoelectric Point: 6.3673

>AT126137 WP_168589814.1 NZ_CP040605:c1109485-1109213 [Saccharopolyspora sp. ASAGF58]
MERIGVRELRQNASRYLKRVAAGESILVTDRGRTVAVLSPPTRDQTLYDELVAAGELIPGEGGELPEPLPAAPTPNVSDR
LLRRREQERF

Nucleotide

• Length: 273 bp

>AT126137 NZ_CP040605:c1109485-1109213 [Saccharopolyspora sp. ASAGF58]
ATGGAGCGGATCGGCGTTCGTGAGCTGCGGCAGAACGCCAGTCGATACCTGAAGCGGGTCGCCGCCGGCGAATCGATCCT
CGTGACCGATCGGGGGCGCACCGTCGCGGTGCTAAGTCCGCCCACGCGTGACCAAACCCTGTACGACGAACTCGTCGCAG
CCGGAGAGCTCATCCCCGGCGAAGGCGGCGAGCTCCCCGAACCGTTGCCGGCAGCGCCGACCCCGAACGTCTCCGACCGG
CTGCTGCGCAGGCGTGAACAGGAGCGGTTTTGA