Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1108821..1109485 Replicon chromosome
Accession NZ_CP040605
Organism Saccharopolyspora sp. ASAGF58

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FDZ84_RS04930 Protein ID WP_168584913.1
Coordinates 1108821..1109216 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FDZ84_RS04935 Protein ID WP_168589814.1
Coordinates 1109213..1109485 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ84_RS04910 1104990..1105709 + 720 WP_168584909.1 FadR family transcriptional regulator -
FDZ84_RS04915 1105734..1105982 - 249 WP_168584910.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
FDZ84_RS04920 1106081..1107601 - 1521 WP_168584911.1 cobyric acid synthase -
FDZ84_RS04925 1107824..1108681 - 858 WP_168584912.1 type I methionyl aminopeptidase -
FDZ84_RS04930 1108821..1109216 - 396 WP_168584913.1 type II toxin-antitoxin system VapC family toxin Toxin
FDZ84_RS04935 1109213..1109485 - 273 WP_168589814.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FDZ84_RS04940 1109543..1111366 - 1824 WP_168584914.1 penicillin-binding protein -
FDZ84_RS04945 1111460..1112296 - 837 WP_168589815.1 GNAT family N-acetyltransferase -
FDZ84_RS04950 1112493..1113647 - 1155 WP_168584915.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14090.13 Da        Isoelectric Point: 5.1702

>T126137 WP_168584913.1 NZ_CP040605:c1109216-1108821 [Saccharopolyspora sp. ASAGF58]
MIYFDSSALIKLIAPEPESKALSQWIRERWEHPRVTSALSKVDVLRTFREVGPAAEDLASIIVSKIDQLPVKQDVLDVAT
ELRGNVGPVDAIHLASACKIKNGLHAYVSYDPALLAAAEEAGLTTASPGAN

Download         Length: 396 bp

>T126137 NZ_CP040605:c1109216-1108821 [Saccharopolyspora sp. ASAGF58]
TTGATCTATTTCGATTCCTCCGCGCTGATCAAGTTGATCGCCCCCGAGCCGGAGAGCAAGGCGCTGAGCCAATGGATCCG
CGAGCGCTGGGAACACCCCCGCGTGACCAGCGCGTTGTCGAAGGTCGACGTGCTGCGCACCTTCCGTGAGGTAGGGCCGG
CCGCCGAAGACCTGGCGTCGATCATCGTGTCGAAGATCGACCAGCTGCCGGTGAAGCAGGACGTGCTCGACGTGGCCACC
GAGCTGCGTGGCAACGTCGGCCCGGTGGACGCCATCCACCTGGCCTCCGCGTGCAAGATCAAGAACGGTCTGCATGCCTA
CGTCTCGTACGATCCGGCGCTACTGGCTGCGGCGGAAGAAGCAGGGCTGACCACGGCCTCACCAGGCGCGAACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10022.38 Da        Isoelectric Point: 6.3673

>AT126137 WP_168589814.1 NZ_CP040605:c1109485-1109213 [Saccharopolyspora sp. ASAGF58]
MERIGVRELRQNASRYLKRVAAGESILVTDRGRTVAVLSPPTRDQTLYDELVAAGELIPGEGGELPEPLPAAPTPNVSDR
LLRRREQERF

Download         Length: 273 bp

>AT126137 NZ_CP040605:c1109485-1109213 [Saccharopolyspora sp. ASAGF58]
ATGGAGCGGATCGGCGTTCGTGAGCTGCGGCAGAACGCCAGTCGATACCTGAAGCGGGTCGCCGCCGGCGAATCGATCCT
CGTGACCGATCGGGGGCGCACCGTCGCGGTGCTAAGTCCGCCCACGCGTGACCAAACCCTGTACGACGAACTCGTCGCAG
CCGGAGAGCTCATCCCCGGCGAAGGCGGCGAGCTCCCCGAACCGTTGCCGGCAGCGCCGACCCCGAACGTCTCCGACCGG
CTGCTGCGCAGGCGTGAACAGGAGCGGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References