Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 2349583..2350262 Replicon chromosome
Accession NZ_CP040593
Organism Klebsiella pneumoniae subsp. pneumoniae strain KpvST15_NDM

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag FFY44_RS11315 Protein ID WP_020324801.1
Coordinates 2349921..2350262 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag FFY44_RS11310 Protein ID WP_020324792.1
Coordinates 2349583..2349900 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFY44_RS11285 2344797..2347949 + 3153 WP_022631414.1 AIDA repeat-containing protein -
FFY44_RS11290 2348042..2348281 + 240 WP_020324820.1 DUF905 domain-containing protein -
FFY44_RS11295 2348384..2348842 + 459 WP_020324813.1 antirestriction protein -
FFY44_RS11300 2348858..2349334 + 477 WP_020324797.1 RadC family protein -
FFY44_RS11305 2349343..2349570 + 228 WP_020324796.1 DUF987 domain-containing protein -
FFY44_RS11310 2349583..2349900 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FFY44_RS11315 2349921..2350262 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
FFY44_RS11320 2350378..2351211 + 834 WP_020324805.1 DUF4942 domain-containing protein -
FFY44_RS11330 2351514..2352020 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
FFY44_RS11335 2352120..2353961 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimA / fimI / fimC / fimD / fimD / fimF / fimG 2302825..2355925 53100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T126117 WP_020324801.1 NZ_CP040593:2349921-2350262 [Klebsiella pneumoniae subsp. pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T126117 NZ_CP040593:2349921-2350262 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT126117 WP_020324792.1 NZ_CP040593:2349583-2349900 [Klebsiella pneumoniae subsp. pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT126117 NZ_CP040593:2349583-2349900 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References