Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1083522..1084038 Replicon chromosome
Accession NZ_CP040593
Organism Klebsiella pneumoniae subsp. pneumoniae strain KpvST15_NDM

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag FFY44_RS05145 Protein ID WP_004178374.1
Coordinates 1083522..1083806 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FFY44_RS05150 Protein ID WP_002886901.1
Coordinates 1083796..1084038 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFY44_RS05125 1079006..1079314 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
FFY44_RS29305 1079399..1079572 + 174 WP_032408826.1 hypothetical protein -
FFY44_RS05130 1079575..1080318 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FFY44_RS05135 1080675..1082813 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FFY44_RS05140 1083054..1083518 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FFY44_RS05145 1083522..1083806 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFY44_RS05150 1083796..1084038 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FFY44_RS05155 1084116..1086026 - 1911 WP_004178373.1 BglG family transcription antiterminator -
FFY44_RS05160 1086049..1087203 - 1155 WP_004178372.1 lactonase family protein -
FFY44_RS05165 1087270..1088010 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T126113 WP_004178374.1 NZ_CP040593:c1083806-1083522 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T126113 NZ_CP040593:c1083806-1083522 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT126113 WP_002886901.1 NZ_CP040593:c1084038-1083796 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT126113 NZ_CP040593:c1084038-1083796 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References