Detailed information of TA system TA126108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 121837..122347
• Replicon: chromosome
• Accession: NZ_CP040587
• Organism: Furfurilactobacillus rossiae strain L2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LROSL2_RS00520
• Protein ID: WP_161000715.1
• Coordinates: 122090..122347 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: -
• Locus tag: LROSL2_RS00515
• Protein ID: WP_178941775.1
• Coordinates: 121837..122097 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LROSL2_RS00505	117501..118586	+	1086	WP_178943423.1	carbamoyl phosphate synthase small subunit	-
LROSL2_RS00510	118579..121755	+	3177	WP_161000717.1	carbamoyl-phosphate synthase large subunit	-
LROSL2_RS00515	121837..122097	+	261	WP_178941775.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LROSL2_RS00520	122090..122347	+	258	WP_161000715.1	Txe/YoeB family addiction module toxin	Toxin
LROSL2_RS00525	122417..123295	-	879	WP_161000714.1	DMT family transporter	-
LROSL2_RS00530	123466..123828	+	363	WP_161000713.1	bacteriocin immunity protein	-
LROSL2_RS00535	123926..125098	-	1173	WP_017261324.1	iron-containing alcohol dehydrogenase	-
LROSL2_RS00540	125365..126609	-	1245	WP_178941776.1	peptidoglycan bridge formation glycyltransferase FemA/FemB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10359.86 Da
• Isoelectric Point: 9.6410

>T126108 WP_161000715.1 NZ_CP040587:122090-122347 [Furfurilactobacillus rossiae]
MIKLWTDDAWNDYMYWHKSGDKRTVKRINELLKSIDRTPFTGIGKPEALRYQFEGKWSRRIDAMNRLVYQIDNNQLIIYS
CKDHY

Nucleotide

• Length: 258 bp

>T126108 NZ_CP040587:122090-122347 [Furfurilactobacillus rossiae]
ATGATTAAATTGTGGACGGACGATGCATGGAATGACTATATGTATTGGCATAAATCTGGTGACAAGAGAACGGTTAAACG
TATCAATGAACTGTTAAAGAGTATCGACAGGACGCCCTTTACAGGGATAGGCAAGCCAGAAGCACTAAGATATCAATTCG
AAGGCAAATGGTCACGCCGAATTGATGCAATGAATCGGTTAGTGTATCAAATCGACAATAACCAGCTGATAATTTACTCT
TGTAAGGATCATTATTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9771.01 Da
• Isoelectric Point: 4.4141

>AT126108 WP_178941775.1 NZ_CP040587:121837-122097 [Furfurilactobacillus rossiae]
MDAITYSTFRQGLKGYMKQINDDSVPMIITNKDSKDDVVVIGKRDYDAMLETIHVMSNPYLAEKIDKGEQQYLAGNVSQH
TLLEDD

Nucleotide

• Length: 261 bp

>AT126108 NZ_CP040587:121837-122097 [Furfurilactobacillus rossiae]
ATGGATGCAATTACGTACTCAACGTTTAGGCAGGGCCTGAAAGGTTACATGAAGCAAATCAACGATGATTCGGTGCCAAT
GATTATTACGAATAAGGATTCCAAAGATGATGTTGTTGTCATTGGGAAACGTGACTATGATGCTATGTTGGAGACCATTC
ATGTCATGTCTAACCCTTACCTAGCCGAAAAAATCGATAAGGGTGAACAACAATATTTGGCTGGCAATGTTAGTCAGCAC
ACGTTGCTAGAAGATGATTAA