Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 33426..33973 Replicon plasmid unnamed
Accession NZ_CP040574
Organism Salmonella enterica subsp. enterica serovar Typhi strain WGS1146

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag FFM56_RS00195 Protein ID WP_000969996.1
Coordinates 33426..33707 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1M1SX19
Locus tag FFM56_RS00200 Protein ID WP_021546940.1
Coordinates 33704..33973 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFM56_RS00165 29242..29931 + 690 WP_001764183.1 hypothetical protein -
FFM56_RS00170 30275..30979 + 705 WP_001067852.1 IS6-like element IS26 family transposase -
FFM56_RS00180 31034..32584 + 1551 Protein_31 Tn3-like element TnAs1 family transposase -
FFM56_RS00185 32885..33094 - 210 Protein_32 transposase -
FFM56_RS00190 33162..33380 - 219 WP_021546941.1 hypothetical protein -
FFM56_RS00195 33426..33707 - 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFM56_RS00200 33704..33973 - 270 WP_021546940.1 hypothetical protein Antitoxin
FFM56_RS00210 34720..35331 + 612 Protein_36 IS3 family transposase -
FFM56_RS00215 35363..35542 - 180 WP_012600012.1 hypothetical protein -
FFM56_RS00220 35766..36083 + 318 WP_032156934.1 hypothetical protein -
FFM56_RS00225 36152..37078 + 927 WP_000617209.1 WYL domain-containing protein -
FFM56_RS00230 37088..37687 + 600 WP_001021938.1 DUF1819 family protein -
FFM56_RS00235 37684..38268 + 585 WP_000645940.1 DUF1788 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..84498 84498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 13852.62 Da        Isoelectric Point: 5.5500

>T126106 WP_000969996.1 NZ_CP040574:c33707-33426 [Salmonella enterica subsp. enterica serovar Typhi]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Download         Length: 282 bp

>T126106 NZ_CP040574:c33707-33426 [Salmonella enterica subsp. enterica serovar Typhi]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 13263.91 Da        Isoelectric Point: 5.5500

>AT126106 WP_021546940.1 NZ_CP040574:c33973-33704 [Salmonella enterica subsp. enterica serovar Typhi]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Download         Length: 270 bp

>AT126106 NZ_CP040574:c33973-33704 [Salmonella enterica subsp. enterica serovar Typhi]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1SX19

References