Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3503326..3503804 Replicon chromosome
Accession NZ_CP040572
Organism Escherichia coli O157:H7 strain ECP17-46

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FGA21_RS18535 Protein ID WP_001303876.1
Coordinates 3503517..3503804 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FGA21_RS18530 Protein ID WP_000536233.1
Coordinates 3503326..3503517 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGA21_RS18495 3498730..3499500 - 771 WP_000450992.1 DUF1627 domain-containing protein -
FGA21_RS18500 3499522..3500268 - 747 WP_000788745.1 ATP-binding protein -
FGA21_RS18505 3500275..3501366 - 1092 WP_001205823.1 hypothetical protein -
FGA21_RS18510 3501445..3501900 + 456 WP_000273724.1 hypothetical protein -
FGA21_RS18515 3502107..3502532 - 426 WP_000693855.1 Rha family transcriptional regulator -
FGA21_RS18520 3502516..3502788 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FGA21_RS18525 3502897..3503298 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FGA21_RS18530 3503326..3503517 + 192 WP_000536233.1 hypothetical protein Antitoxin
FGA21_RS18535 3503517..3503804 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGA21_RS18545 3504082..3504237 + 156 WP_000379575.1 DUF1391 family protein -
FGA21_RS18550 3504379..3504768 + 390 WP_000394511.1 hypothetical protein -
FGA21_RS18555 3504955..3505140 - 186 WP_001133046.1 hypothetical protein -
FGA21_RS18565 3505714..3505902 + 189 WP_000413705.1 cell division inhibition protein DicB -
FGA21_RS18570 3505899..3506090 + 192 WP_001098307.1 DUF1482 family protein -
FGA21_RS18575 3506184..3508655 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T126094 WP_001303876.1 NZ_CP040572:3503517-3503804 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T126094 NZ_CP040572:3503517-3503804 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT126094 WP_000536233.1 NZ_CP040572:3503326-3503517 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT126094 NZ_CP040572:3503326-3503517 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References