Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2301487..2302282 Replicon chromosome
Accession NZ_CP040572
Organism Escherichia coli O157:H7 strain ECP17-46

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag FGA21_RS11810 Protein ID WP_000854914.1
Coordinates 2301908..2302282 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag FGA21_RS11805 Protein ID WP_001280954.1
Coordinates 2301487..2301861 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGA21_RS11770 2296842..2297747 + 906 WP_000203541.1 chemotaxis protein -
FGA21_RS11775 2297744..2298814 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
FGA21_RS11785 2299154..2299972 + 819 WP_001234682.1 DUF945 domain-containing protein -
FGA21_RS11790 2300063..2300548 + 486 WP_000214398.1 antirestriction protein -
FGA21_RS11795 2300564..2301040 + 477 WP_001186738.1 RadC family protein -
FGA21_RS11800 2301103..2301324 + 222 WP_001220314.1 DUF987 domain-containing protein -
FGA21_RS11805 2301487..2301861 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FGA21_RS11810 2301908..2302282 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
FGA21_RS11815 2302279..2302770 + 492 WP_000976853.1 hypothetical protein -
FGA21_RS11820 2302782..2302979 + 198 WP_000839282.1 DUF957 domain-containing protein -
FGA21_RS11825 2303064..2303906 + 843 WP_001280481.1 DUF4942 domain-containing protein -
FGA21_RS11835 2304377..2305315 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
FGA21_RS11840 2305370..2306107 + 738 WP_000283664.1 zinc-binding phosphatase -
FGA21_RS11845 2306131..2306685 + 555 WP_001001917.1 molecular chaperone YcdY -
FGA21_RS11850 2306787..2307278 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T126077 WP_000854914.1 NZ_CP040572:2301908-2302282 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T126077 NZ_CP040572:2301908-2302282 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT126077 WP_001280954.1 NZ_CP040572:2301487-2301861 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT126077 NZ_CP040572:2301487-2301861 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References