Detailed information of TA system TA126032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 67695..68220
• Replicon: plasmid pCFSAN059542
• Accession: NZ_CP040569
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SAP17-8290

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FGA22_RS25030
• Protein ID: WP_001159863.1
• Coordinates: 67695..68000 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FGA22_RS25035
• Protein ID: WP_000813641.1
• Coordinates: 68002..68220 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGA22_RS24985	63074..63634	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
FGA22_RS25320	63790..64077	+	288	WP_071530243.1	hypothetical protein	-
FGA22_RS24995	64354..64839	-	486	WP_000905606.1	membrane protein	-
FGA22_RS25000	64833..65342	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FGA22_RS25010	65346..66059	-	714	Protein_80	EAL domain-containing protein	-
FGA22_RS25015	66068..66850	-	783	WP_000082169.1	site-specific integrase	-
FGA22_RS25020	66885..67406	-	522	WP_000198608.1	hypothetical protein	-
FGA22_RS25025	67403..67693	-	291	WP_001266176.1	hypothetical protein	-
FGA22_RS25030	67695..68000	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FGA22_RS25035	68002..68220	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FGA22_RS25040	68896..69417	+	522	WP_010999942.1	hypothetical protein	-
FGA22_RS25050	69901..70197	+	297	WP_001687482.1	hypothetical protein	-
FGA22_RS25055	70691..71680	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
FGA22_RS25060	71939..72275	-	337	Protein_89	site-specific integrase	-
FGA22_RS25065	72552..72933	-	382	Protein_90	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94033	94033

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Arc-like DNA binding domain (5-46)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T126032 WP_001159863.1 NZ_CP040569:c68000-67695 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T126032 NZ_CP040569:c68000-67695 [Salmonella enterica subsp. enterica serovar Typhimurium]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT126032 WP_000813641.1 NZ_CP040569:c68220-68002 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT126032 NZ_CP040569:c68220-68002 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6