Detailed information of TA system TA126030

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 62855..63380
• Replicon: plasmid pCFSAN059544
• Accession: NZ_CP040565
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SAP17-7699

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FGA24_RS24370
• Protein ID: WP_001159863.1
• Coordinates: 63075..63380 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FGA24_RS24365
• Protein ID: WP_000813641.1
• Coordinates: 62855..63073 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGA24_RS24335	58142..58523	+	382	Protein_68	YgiW/YdeI family stress tolerance OB fold protein	-
FGA24_RS24340	58800..59136	+	337	Protein_69	site-specific integrase	-
FGA24_RS24345	59395..60384	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
FGA24_RS24350	60878..61174	-	297	WP_001687482.1	hypothetical protein	-
FGA24_RS24360	61658..62179	-	522	WP_010999942.1	hypothetical protein	-
FGA24_RS24365	62855..63073	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FGA24_RS24370	63075..63380	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FGA24_RS24375	63382..63672	+	291	WP_001266176.1	hypothetical protein	-
FGA24_RS24380	63669..64190	+	522	WP_000198608.1	hypothetical protein	-
FGA24_RS24385	64225..65007	+	783	WP_000082169.1	site-specific integrase	-
FGA24_RS24390	65016..65729	+	714	Protein_78	EAL domain-containing protein	-
FGA24_RS24400	65733..66242	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FGA24_RS24405	66236..66721	+	486	WP_000905606.1	membrane protein	-
FGA24_RS24410	66998..67285	-	288	WP_071530243.1	hypothetical protein	-
FGA24_RS24415	67441..68001	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93869	93869

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Toxin HigB-like (40-89)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T126030 WP_001159863.1 NZ_CP040565:63075-63380 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T126030 NZ_CP040565:63075-63380 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT126030 WP_000813641.1 NZ_CP040565:62855-63073 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT126030 NZ_CP040565:62855-63073 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6