Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1473251..1473887 Replicon chromosome
Accession NZ_CP040553
Organism Parageobacillus caldoxylosilyticus strain ER4B

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag BV455_RS07480 Protein ID WP_003253417.1
Coordinates 1473251..1473601 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A023DG03
Locus tag BV455_RS07485 Protein ID WP_017435868.1
Coordinates 1473606..1473887 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV455_RS07465 (BV455_01513) 1469937..1470407 - 471 WP_017435865.1 SprT family protein -
BV455_RS07470 1470497..1470610 + 114 WP_017435866.1 cortex morphogenetic protein CmpA -
BV455_RS07475 (BV455_01514) 1470605..1472791 - 2187 WP_081161036.1 Tex family protein -
BV455_RS07480 (BV455_01515) 1473251..1473601 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BV455_RS07485 (BV455_01516) 1473606..1473887 - 282 WP_017435868.1 hypothetical protein Antitoxin
BV455_RS07490 (BV455_01517) 1474001..1475167 - 1167 WP_026078517.1 alanine racemase -
BV455_RS07495 (BV455_01518) 1475360..1476373 - 1014 WP_042409268.1 outer membrane lipoprotein carrier protein LolA -
BV455_RS07500 (BV455_01519) 1476456..1476815 - 360 WP_218687909.1 holo-ACP synthase -
BV455_RS07505 (BV455_01520) 1476949..1477566 + 618 WP_081161017.1 rhomboid family intramembrane serine protease -
BV455_RS07510 1477633..1477881 - 249 WP_042409264.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T126014 WP_003253417.1 NZ_CP040553:c1473601-1473251 [Parageobacillus caldoxylosilyticus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T126014 NZ_CP040553:c1473601-1473251 [Parageobacillus caldoxylosilyticus]
TTGATTGTTAAACGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTAGTTGGCTCAGAGCAGGGCGGTGTCCGCCCCGT
ATTGGTCATCCAAAATGACATTGGCAATCGCTTTAGCCCAACGGTGATCGTAGCGGCGATTACAGCGCAAATTCAAAAAG
CGAAGCTGCCAACGCACGTTGAAATTGATGCAAAACGCTACGGGTTTGAGCGGGATTCCGTCATTTTGCTAGAACAAATT
CGGACAATTGATAAACAGCGGCTCACGGATAAAATCACCCATTTAGATGATGAAATGATGGATAAAGTGGATGAAGCGCT
GCAGATCAGTTTAGGACTTATCGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10661.19 Da        Isoelectric Point: 7.0147

>AT126014 WP_017435868.1 NZ_CP040553:c1473887-1473606 [Parageobacillus caldoxylosilyticus]
VSESSATTEIVVRLPQSLVTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT126014 NZ_CP040553:c1473887-1473606 [Parageobacillus caldoxylosilyticus]
GTGTCGGAGTCTAGCGCAACAACGGAAATCGTCGTTCGTTTGCCTCAATCATTAGTAACAGAATTAGATGTGCTGGTGAA
ACAAGAAAACGGCAATCGGAATGAACTGATTTACCAAGCGACGAAAATGTATATTCGTGAGCGGAAGAAACGGCAAATCC
GCGAAGCGATGAGACGAGGCTACATGGAAATGGCAAAAATCAATTTATCGATCGCTTCAGAAGCGTTTCTTGCAGAATAT
GAAGCCGACCACACCGTTGAACGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A023DG03

References