Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2423247..2423901 Replicon chromosome
Accession NZ_CP040539
Organism Klebsiella pneumoniae strain CR-HvKP4

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag FFT48_RS11860 Protein ID WP_004144731.1
Coordinates 2423494..2423901 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FFT48_RS11855 Protein ID WP_002916312.1
Coordinates 2423247..2423513 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFT48_RS11830 2418403..2419836 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
FFT48_RS11835 2419955..2420683 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FFT48_RS11840 2420733..2421044 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FFT48_RS11845 2421208..2421867 + 660 WP_002916317.1 hemolysin III family protein -
FFT48_RS11850 2422018..2423001 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FFT48_RS11855 2423247..2423513 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FFT48_RS11860 2423494..2423901 + 408 WP_004144731.1 protein YgfX Toxin
FFT48_RS11865 2423908..2424429 - 522 WP_002916308.1 flavodoxin FldB -
FFT48_RS11870 2424530..2425426 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FFT48_RS11875 2425449..2426162 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FFT48_RS11880 2426168..2427901 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T125956 WP_004144731.1 NZ_CP040539:2423494-2423901 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T125956 NZ_CP040539:2423494-2423901 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT125956 WP_002916312.1 NZ_CP040539:2423247-2423513 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT125956 NZ_CP040539:2423247-2423513 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References