Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 7828..8408 Replicon plasmid pCR-HvKP1-p4
Accession NZ_CP040537
Organism Klebsiella pneumoniae strain CR-HvKP1

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag FFT47_RS29820 Protein ID WP_071177730.1
Coordinates 7828..8142 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag FFT47_RS29825 Protein ID WP_000093040.1
Coordinates 8130..8408 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFT47_RS29795 3772..5736 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
FFT47_RS29800 5736..6467 + 732 WP_071177728.1 replication-relaxation family protein -
FFT47_RS29805 6474..7004 + 531 WP_071177729.1 hypothetical protein -
FFT47_RS29810 7031..7210 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
FFT47_RS29815 7236..7664 - 429 WP_001140599.1 hypothetical protein -
FFT47_RS29820 7828..8142 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFT47_RS29825 8130..8408 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
FFT47_RS30590 8742..8948 - 207 Protein_10 TonB family protein -
FFT47_RS29835 8945..9316 - 372 WP_001237044.1 cell envelope integrity protein TolA -
FFT47_RS29840 9590..9835 - 246 WP_032440458.1 hypothetical protein -
FFT47_RS29850 10480..11967 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T125946 WP_071177730.1 NZ_CP040537:c8142-7828 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T125946 NZ_CP040537:c8142-7828 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT125946 WP_000093040.1 NZ_CP040537:c8408-8130 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT125946 NZ_CP040537:c8408-8130 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References