Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 773026..774056 Replicon chromosome
Accession NZ_CP040525
Organism Corynebacterium diphtheriae strain CD1008

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag FE376_RS03810 Protein ID WP_070794874.1
Coordinates 773026..773445 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag FE376_RS03815 Protein ID WP_070794877.1
Coordinates 773490..774056 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE376_RS03795 (FE376_03990) 769682..770536 + 855 WP_014303121.1 hypothetical protein -
FE376_RS03800 (FE376_03995) 770529..771437 - 909 WP_014310191.1 DUF1906 domain-containing protein -
FE376_RS03805 (FE376_04000) 771566..772766 - 1201 Protein_741 cation:proton antiporter -
FE376_RS03810 (FE376_04015) 773026..773445 - 420 WP_070794874.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FE376_RS03815 (FE376_04020) 773490..774056 - 567 WP_070794877.1 Panacea domain-containing protein Antitoxin
FE376_RS03820 774389..774664 + 276 WP_014309249.1 hypothetical protein -
FE376_RS03830 (FE376_04035) 775336..775611 + 276 WP_014303127.1 hypothetical protein -
FE376_RS03835 (FE376_04040) 775618..776370 + 753 WP_014306660.1 precorrin-6A synthase (deacetylating) -
FE376_RS03840 (FE376_04045) 776389..776646 - 258 WP_070794878.1 mycoredoxin -
FE376_RS03845 (FE376_04050) 776667..777170 - 504 WP_072567275.1 dihydrofolate reductase -
FE376_RS03850 (FE376_04055) 777170..777982 - 813 WP_014318827.1 thymidylate synthase -
FE376_RS03855 (FE376_04060) 778076..778834 - 759 WP_070794880.1 3'(2'),5'-bisphosphate nucleotidase CysQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(11-93)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15477.61 Da        Isoelectric Point: 8.2756

>T125900 WP_070794874.1 NZ_CP040525:c773445-773026 [Corynebacterium diphtheriae]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 420 bp

>T125900 NZ_CP040525:c773445-773026 [Corynebacterium diphtheriae]
ATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTGCGGGAAGCGAACAGGTCCTCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGGCG
TCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGA
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21064.47 Da        Isoelectric Point: 4.5581

>AT125900 WP_070794877.1 NZ_CP040525:c774056-773490 [Corynebacterium diphtheriae]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
STALDSLEQAADDVATENAETLRLLAFI

Download         Length: 567 bp

>AT125900 NZ_CP040525:c774056-773490 [Corynebacterium diphtheriae]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCACGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTACTGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References