Detailed information of TA system TA125897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2369771..2370254
• Replicon: chromosome
• Accession: NZ_CP040521
• Organism: Corynebacterium diphtheriae strain CD1036

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6J4WN23
• Locus tag: FE380_RS11435
• Protein ID: WP_014307502.1
• Coordinates: 2369771..2370040 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: FE380_RS11440
• Protein ID: WP_014304050.1
• Coordinates: 2370021..2370254 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE380_RS11410 (FE380_11635)	2365005..2365218	-	214	Protein_2231	integrase core domain-containing protein	-
FE380_RS11415 (FE380_11640)	2365226..2366629	-	1404	Protein_2232	IS30 family transposase	-
FE380_RS11420 (FE380_11645)	2366759..2366932	-	174	WP_143337889.1	transposase	-
FE380_RS11425 (FE380_11650)	2367099..2367239	-	141	WP_179143934.1	hypothetical protein	-
FE380_RS11430 (FE380_11655)	2367615..2369435	+	1821	WP_072590227.1	N-acetylmuramoyl-L-alanine amidase	-
FE380_RS11435 (FE380_11660)	2369771..2370040	-	270	WP_014307502.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FE380_RS11440 (FE380_11665)	2370021..2370254	-	234	WP_014304050.1	ribbon-helix-helix protein, CopG family	Antitoxin
FE380_RS11445 (FE380_11670)	2370944..2372275	-	1332	WP_047939474.1	ATP-binding protein	-
FE380_RS11450 (FE380_11675)	2372370..2373704	-	1335	WP_081370805.1	restriction endonuclease subunit S	-
FE380_RS11455 (FE380_11680)	2373705..2375114	-	1410	WP_072590225.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2361473..2378365	16892
	-	flank	IS/Tn	-	-	2365526..2366665	1139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10338.92 Da
• Isoelectric Point: 10.6099

>T125897 WP_014307502.1 NZ_CP040521:c2370040-2369771 [Corynebacterium diphtheriae]
VTSWTIEFSPRAAKELRKLDRPVQKRIVAYLREISTLPNPQMRGKALTGNWAGFWRWRVGDYRLVAAIEDDRVVIVVVSI
GHRSQVYED

Nucleotide

• Length: 270 bp

>T125897 NZ_CP040521:c2370040-2369771 [Corynebacterium diphtheriae]
GTGACCTCTTGGACGATTGAGTTTTCTCCACGTGCTGCTAAAGAGCTCCGGAAGCTTGACCGGCCAGTTCAAAAGCGCAT
TGTTGCGTATCTTCGAGAAATTTCTACTCTGCCCAATCCGCAAATGCGTGGTAAGGCGTTAACTGGCAACTGGGCAGGTT
TTTGGCGTTGGCGTGTGGGGGATTACCGCCTCGTTGCAGCTATTGAAGATGATCGTGTTGTCATCGTTGTTGTTTCCATT
GGTCACCGATCTCAGGTTTACGAGGACTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8975.96 Da
• Isoelectric Point: 4.3904

>AT125897 WP_014304050.1 NZ_CP040521:c2370254-2370021 [Corynebacterium diphtheriae]
MSNPVISLRIGASEKERLDELSRRTGRSGSFYIREALEKHLDELEYVYGVRSEYEAIRRGELETISLDEVERDLLDD

Nucleotide

• Length: 234 bp

>AT125897 NZ_CP040521:c2370254-2370021 [Corynebacterium diphtheriae]
ATGAGCAATCCTGTTATTAGCCTACGTATCGGGGCGAGTGAAAAAGAGCGGCTTGATGAGCTATCACGGCGTACCGGCCG
GTCAGGATCTTTTTACATACGAGAAGCCTTAGAAAAACATCTTGACGAGCTTGAGTACGTCTATGGCGTTCGCAGCGAGT
ACGAAGCTATCCGACGCGGAGAGCTAGAGACAATCAGCTTGGACGAGGTAGAGCGTGACCTCTTGGACGATTGA

Structures

Toxin

• AlphaFold DB: A0A6J4WN23