Detailed information of TA system TA125895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 124293..124776
• Replicon: chromosome
• Accession: NZ_CP040521
• Organism: Corynebacterium diphtheriae strain CD1036

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1X4MAI5
• Locus tag: FE380_RS00665
• Protein ID: WP_003850119.1
• Coordinates: 124513..124776 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: FE380_RS00660
• Protein ID: WP_003850117.1
• Coordinates: 124293..124529 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE380_RS00630 (FE380_00675)	119683..119994	+	312	WP_077393411.1	LysE family transporter	-
FE380_RS00635 (FE380_00680)	119957..120151	+	195	WP_199321707.1	hypothetical protein	-
FE380_RS00640 (FE380_00685)	120261..121019	+	759	WP_014317428.1	hypothetical protein	-
FE380_RS00645	121237..122148	+	912	WP_014317429.1	helix-turn-helix domain-containing protein	-
FE380_RS00650	122070..122822	+	753	WP_235696310.1	IS30 family transposase	-
FE380_RS00655 (FE380_00695)	123034..123717	-	684	WP_072564828.1	hypothetical protein	-
FE380_RS00660 (FE380_00705)	124293..124529	+	237	WP_003850117.1	ribbon-helix-helix domain-containing protein	Antitoxin
FE380_RS00665 (FE380_00710)	124513..124776	+	264	WP_003850119.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FE380_RS00670 (FE380_00715)	124902..125195	+	294	WP_014302727.1	RNA-binding S4 domain-containing protein	-
FE380_RS00675 (FE380_00720)	125195..126019	+	825	WP_014301205.1	VOC family protein	-
FE380_RS00680 (FE380_00725)	126025..126330	+	306	WP_003850125.1	MGMT family protein	-
FE380_RS00685 (FE380_00730)	126340..127260	-	921	WP_021335362.1	alpha/beta hydrolase	-
FE380_RS00690 (FE380_00735)	127400..128026	+	627	WP_003850128.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	88592..125195	36603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (7-43)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9939.50 Da
• Isoelectric Point: 10.9201

>T125895 WP_003850119.1 NZ_CP040521:124513-124776 [Corynebacterium diphtheriae]
VAWEISFSPRAVKSFKKLDTGEQRRVSKFLREVGALEDPRLRGKALTANKSGLWRWRVGDYRIIADIVDARVVVVVVDVG
HRSKVYD

Nucleotide

• Length: 264 bp

>T125895 NZ_CP040521:124513-124776 [Corynebacterium diphtheriae]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGTGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGTCTACGACTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8911.02 Da
• Isoelectric Point: 4.8604

>AT125895 WP_003850117.1 NZ_CP040521:124293-124529 [Corynebacterium diphtheriae]
MSGSVISLRIDDEQKRRLDELSRRTGRPCSFYLREALSAHLADLEYVYRLEEEAAQVRRGELGTVPLSQLERECGLGD

Nucleotide

• Length: 237 bp

>AT125895 NZ_CP040521:124293-124529 [Corynebacterium diphtheriae]
ATGAGTGGTTCGGTGATTAGCTTGCGTATCGATGACGAGCAGAAGCGGCGTTTGGATGAGCTGTCGCGACGTACGGGGCG
GCCGTGTTCGTTTTATCTTCGGGAAGCGTTGAGTGCACATCTGGCTGATCTGGAGTATGTGTATCGCTTGGAGGAGGAGG
CTGCTCAGGTTCGTCGTGGGGAGTTGGGAACTGTGCCGTTGAGTCAGCTGGAGCGCGAGTGTGGCTTGGGAGATTAG

Structures

Toxin

• AlphaFold DB: A0A1X4MAI5