Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 805661..806691 | Replicon | chromosome |
| Accession | NZ_CP040520 | ||
| Organism | Corynebacterium diphtheriae strain CD1040 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | FE381_RS03950 | Protein ID | WP_235696373.1 |
| Coordinates | 805661..806080 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | Q6NIH9 |
| Locus tag | FE381_RS03955 | Protein ID | WP_010934564.1 |
| Coordinates | 806125..806691 (-) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FE381_RS03935 (FE381_04125) | 802319..803173 | + | 855 | WP_072564661.1 | hypothetical protein | - |
| FE381_RS03940 (FE381_04130) | 803166..804074 | - | 909 | WP_014303122.1 | DUF1906 domain-containing protein | - |
| FE381_RS03945 (FE381_04135) | 804203..805402 | - | 1200 | WP_014310192.1 | cation:proton antiporter | - |
| FE381_RS03950 (FE381_04145) | 805661..806080 | - | 420 | WP_235696373.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| FE381_RS03955 (FE381_04150) | 806125..806691 | - | 567 | WP_010934564.1 | Panacea domain-containing protein | Antitoxin |
| FE381_RS03960 | 807024..807299 | + | 276 | WP_014309249.1 | hypothetical protein | - |
| FE381_RS03970 (FE381_04165) | 807971..808246 | + | 276 | WP_072564659.1 | hypothetical protein | - |
| FE381_RS03975 (FE381_04170) | 808253..809005 | + | 753 | WP_072564658.1 | precorrin-6A synthase (deacetylating) | - |
| FE381_RS03980 (FE381_04175) | 809024..809281 | - | 258 | WP_010934589.1 | mycoredoxin | - |
| FE381_RS03985 (FE381_04180) | 809302..809805 | - | 504 | WP_110217582.1 | dihydrofolate reductase | - |
| FE381_RS03990 (FE381_04185) | 809805..810617 | - | 813 | WP_014303130.1 | thymidylate synthase | - |
| FE381_RS03995 (FE381_04190) | 810711..811469 | - | 759 | WP_010934592.1 | 3'(2'),5'-bisphosphate nucleotidase CysQ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 805661..816322 | 10661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15500.68 Da Isoelectric Point: 8.7021
>T125894 WP_235696373.1 NZ_CP040520:c806080-805661 [Corynebacterium diphtheriae]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSVDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSVDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 420 bp
>T125894 NZ_CP040520:c806080-805661 [Corynebacterium diphtheriae]
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTCCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGGTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTCCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGGTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
Antitoxin
Download Length: 189 a.a. Molecular weight: 21022.71 Da Isoelectric Point: 4.6246
>AT125894 WP_010934564.1 NZ_CP040520:c806691-806125 [Corynebacterium diphtheriae]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
>AT125894 NZ_CP040520:c806691-806125 [Corynebacterium diphtheriae]
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGTTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCGTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGTTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCGTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|