Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 743656..744686 | Replicon | chromosome |
| Accession | NZ_CP040519 | ||
| Organism | Corynebacterium diphtheriae strain CD1075 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | FE382_RS03645 | Protein ID | WP_199323653.1 |
| Coordinates | 743656..744075 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | FE382_RS03650 | Protein ID | WP_235697729.1 |
| Coordinates | 744120..744686 (-) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FE382_RS03630 (FE382_03760) | 740313..741167 | + | 855 | WP_010934561.1 | hypothetical protein | - |
| FE382_RS03635 (FE382_03765) | 741160..742068 | - | 909 | WP_014301586.1 | DUF1906 domain-containing protein | - |
| FE382_RS03640 (FE382_03770) | 742197..743396 | - | 1200 | WP_010934563.1 | cation:proton antiporter | - |
| FE382_RS03645 (FE382_03785) | 743656..744075 | - | 420 | WP_199323653.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| FE382_RS03650 (FE382_03790) | 744120..744686 | - | 567 | WP_235697729.1 | Panacea domain-containing protein | Antitoxin |
| FE382_RS03655 | 744897..745097 | + | 201 | WP_196970851.1 | hypothetical protein | - |
| FE382_RS03660 | 745072..745347 | + | 276 | WP_014309249.1 | hypothetical protein | - |
| FE382_RS03665 (FE382_03800) | 745900..746838 | - | 939 | WP_014309250.1 | tyrosine recombinase XerC | - |
| FE382_RS03670 (FE382_03805) | 746950..748050 | - | 1101 | WP_014309251.1 | hypothetical protein | - |
| FE382_RS03675 (FE382_03810) | 748238..748564 | + | 327 | WP_014309252.1 | helix-turn-helix transcriptional regulator | - |
| FE382_RS03680 (FE382_03815) | 748847..749629 | + | 783 | WP_014309253.1 | integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 743656..752209 | 8553 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15449.59 Da Isoelectric Point: 8.2743
>T125893 WP_199323653.1 NZ_CP040519:c744075-743656 [Corynebacterium diphtheriae]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDGSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDGSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 420 bp
>T125893 NZ_CP040519:c744075-743656 [Corynebacterium diphtheriae]
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATGGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATGGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
Antitoxin
Download Length: 189 a.a. Molecular weight: 20963.64 Da Isoelectric Point: 4.5262
>AT125893 WP_235697729.1 NZ_CP040519:c744686-744120 [Corynebacterium diphtheriae]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLPADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLPADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
>AT125893 NZ_CP040519:c744686-744120 [Corynebacterium diphtheriae]
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCCTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCCTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|