Detailed information of TA system TA125892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2840941..2841506
• Replicon: chromosome
• Accession: NZ_CP040518
• Organism: Blautia sp. SC05B48

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3E2XIW6
• Locus tag: EYS05_RS13195
• Protein ID: WP_066085058.1
• Coordinates: 2840941..2841231 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C7H6P4
• Locus tag: EYS05_RS13200
• Protein ID: WP_005924829.1
• Coordinates: 2841228..2841506 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYS05_RS13165	2836097..2837011	+	915	WP_014081148.1	HAMP domain-containing histidine kinase	-
EYS05_RS13170	2837471..2837884	+	414	WP_024724760.1	hypothetical protein	-
EYS05_RS13175	2837988..2838440	+	453	WP_055194993.1	hypothetical protein	-
EYS05_RS13180	2838451..2838912	+	462	WP_138277342.1	sigma-70 family RNA polymerase sigma factor	-
EYS05_RS13185	2838941..2839231	+	291	WP_138277343.1	DUF3847 domain-containing protein	-
EYS05_RS13190	2839418..2840863	+	1446	WP_138277344.1	MobA/MobL family protein	-
EYS05_RS13195	2840941..2841231	-	291	WP_066085058.1	type II toxin-antitoxin system YafQ family toxin	Toxin
EYS05_RS13200	2841228..2841506	-	279	WP_005924829.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EYS05_RS17500	2841613..2841789	+	177	WP_009296691.1	hypothetical protein	-
EYS05_RS13205	2841770..2842168	+	399	WP_138277345.1	cysteine-rich VLP domain-containing protein	-
EYS05_RS13210	2842283..2843017	+	735	WP_138277346.1	phage replisome organizer N-terminal domain-containing protein	-
EYS05_RS13215	2843014..2843877	+	864	WP_138277347.1	ATP-binding protein	-
EYS05_RS13220	2843921..2844115	+	195	WP_118445462.1	transposon-encoded TnpW family protein	-
EYS05_RS13225	2844193..2844558	+	366	WP_009589131.1	hypothetical protein	-
EYS05_RS13230	2844654..2845079	+	426	Protein_2537	TraM recognition domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2833303..3002147	168844

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-90)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11098.84 Da
• Isoelectric Point: 8.0630

>T125892 WP_066085058.1 NZ_CP040518:c2841231-2840941 [Blautia sp. SC05B48]
MKETKYTVKYTTSFKKDYKRAIKRGLKIEVLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Nucleotide

• Length: 291 bp

>T125892 NZ_CP040518:c2841231-2840941 [Blautia sp. SC05B48]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATCGAGGTGCTGGAGCAGGTCGTAGCGTTGCTGGCGATGGGCGAACCGCTGCCAGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCACATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10247.66 Da
• Isoelectric Point: 4.4692

>AT125892 WP_005924829.1 NZ_CP040518:c2841506-2841228 [Blautia sp. SC05B48]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Nucleotide

• Length: 279 bp

>AT125892 NZ_CP040518:c2841506-2841228 [Blautia sp. SC05B48]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTATTTGCTGACCTGAAAAGATGA

Structures

Toxin

• AlphaFold DB: A0A3E2XIW6

Antitoxin

• AlphaFold DB: A0A1M4XB19