Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3052122..3053689 Replicon chromosome
Accession NZ_CP040517
Organism Luteithermobacter gelatinilyticus strain MEBiC09520

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FE788_RS13665 Protein ID WP_138381163.1
Coordinates 3052122..3053435 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FE788_RS13670 Protein ID WP_138381164.1
Coordinates 3053435..3053689 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE788_RS13645 3048171..3049340 - 1170 WP_138381159.1 site-specific integrase -
FE788_RS13650 3049395..3049859 - 465 WP_138381160.1 hypothetical protein -
FE788_RS13655 3050636..3051088 - 453 WP_138381161.1 hypothetical protein -
FE788_RS13665 3052122..3053435 - 1314 WP_138381163.1 type II toxin-antitoxin system HipA family toxin Toxin
FE788_RS13670 3053435..3053689 - 255 WP_138381164.1 helix-turn-helix domain-containing protein Antitoxin
FE788_RS13675 3053833..3054030 + 198 WP_138379465.1 hypothetical protein -
FE788_RS13680 3054049..3055662 + 1614 WP_138381165.1 type I restriction-modification system subunit M -
FE788_RS13685 3055655..3056929 + 1275 WP_138381166.1 restriction endonuclease subunit S -
FE788_RS13690 3056926..3057723 + 798 WP_138381167.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3047241..3077131 29890
- flank IS/Tn - - 3047241..3047612 371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-47)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48480.72 Da        Isoelectric Point: 7.7915

>T125891 WP_138381163.1 NZ_CP040517:c3053435-3052122 [Luteithermobacter gelatinilyticus]
MARRKRHAPLAVYLNSRLVGQLRKAASGAVDFQYDDSWLSWEDAFPISLSLPLREDRYIGAPVIAVFDNLLPDNPDIRRK
LAERARADGTDAFNLLSAIGRDCVGALQFLPEDIAPGPPGGIDARPVSDDEIAALLGDLGNSPLGIGADEEFRISLAGAQ
EKTALLHWKDQWHIPHGTTATTHIFKPEIGKRPDGIDLSLSVENEHLCMTLMNALGLPAAETAIARFGNRKVLVVKRFDR
LWTTDKRLLRLPQEDCCQALSVPPARKYESDGGPGLAGLIGLFTSSDTPLEDQRRIMKAAIVFWLLAATDGHAKNFSLFL
YPRSRFSLTPFYDVMSVQPLYDAKQLQQRQMKMAMAIGKSRHYLVHRISPRHFLETAEACGMGKNIVQELFAELLDRSDK
AIDKTLAALPNGFPHGLTESIIGGYRRRLRQLEAIIT

Download         Length: 1314 bp

>T125891 NZ_CP040517:c3053435-3052122 [Luteithermobacter gelatinilyticus]
ATGGCCCGCCGCAAAAGACATGCCCCGCTTGCGGTTTATCTGAACAGCCGGTTGGTCGGCCAGCTGCGCAAGGCCGCGAG
CGGCGCCGTCGATTTCCAGTATGATGACAGCTGGCTGTCCTGGGAGGATGCTTTCCCGATCTCCCTCTCGCTGCCGCTGC
GCGAGGATCGCTATATCGGCGCGCCGGTGATCGCGGTGTTCGATAATCTGCTCCCGGATAATCCCGATATCCGCCGCAAG
CTTGCCGAACGCGCCCGGGCCGATGGGACCGATGCCTTCAACCTGCTGAGCGCAATCGGCCGCGACTGCGTCGGCGCCCT
GCAGTTCTTGCCCGAAGACATTGCCCCGGGACCGCCCGGCGGGATCGACGCAAGGCCCGTGAGTGACGATGAGATCGCCG
CGCTGCTAGGAGACCTTGGCAATAGTCCGCTCGGCATTGGCGCGGATGAAGAATTCCGGATTTCATTGGCGGGCGCGCAG
GAAAAAACCGCCCTGCTGCATTGGAAGGACCAGTGGCATATCCCGCACGGCACAACGGCGACCACCCACATCTTCAAACC
GGAGATCGGCAAGCGGCCGGACGGCATCGACCTTTCACTCTCGGTCGAGAACGAGCATCTGTGCATGACGCTGATGAATG
CGCTCGGCCTGCCGGCTGCCGAGACTGCAATCGCGCGCTTTGGCAACAGGAAAGTGCTCGTCGTCAAGCGGTTCGACCGG
CTCTGGACCACGGATAAACGGCTGCTGCGCCTGCCGCAGGAAGATTGCTGCCAGGCGTTGTCGGTTCCGCCGGCCCGGAA
ATATGAAAGCGATGGTGGCCCGGGCCTGGCTGGGCTGATTGGCCTGTTCACCAGCAGCGATACGCCCCTTGAGGATCAGC
GGCGGATCATGAAGGCCGCGATTGTGTTCTGGTTGCTCGCCGCGACCGACGGTCACGCCAAGAATTTCAGCCTGTTCCTG
TACCCGCGCAGCCGGTTTTCTCTAACGCCGTTTTACGATGTCATGTCGGTCCAGCCACTCTATGACGCGAAGCAGCTGCA
GCAACGTCAGATGAAAATGGCAATGGCCATCGGTAAAAGCCGGCATTACCTCGTGCATAGAATTTCTCCCCGGCACTTTC
TGGAAACGGCCGAAGCTTGCGGCATGGGCAAAAACATCGTCCAGGAGCTGTTCGCAGAGCTGCTGGATCGCAGCGACAAA
GCTATCGATAAAACGCTGGCCGCGCTGCCGAACGGTTTCCCACATGGCCTCACCGAGTCGATCATTGGCGGCTACCGCCG
CCGCCTGCGCCAGCTGGAAGCGATCATCACCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9215.67 Da        Isoelectric Point: 10.1808

>AT125891 WP_138381164.1 NZ_CP040517:c3053689-3053435 [Luteithermobacter gelatinilyticus]
MTEQIARSEKQLGAILRRVRKQQGLTQSQLGEKIHLRQATISKLEDGAPATQLATVIAALAALDLELVVRPRSQAKPEDI
EGLF

Download         Length: 255 bp

>AT125891 NZ_CP040517:c3053689-3053435 [Luteithermobacter gelatinilyticus]
ATGACCGAACAGATTGCCAGATCAGAAAAACAGCTGGGCGCCATCCTGCGCCGGGTCCGCAAGCAACAGGGCCTGACGCA
ATCCCAGCTCGGCGAAAAAATCCATCTGCGCCAGGCGACCATTTCCAAGCTGGAGGACGGCGCCCCGGCCACGCAGCTTG
CCACGGTCATTGCCGCCCTGGCCGCGCTCGATCTGGAACTTGTCGTCCGGCCGCGCAGCCAGGCCAAGCCCGAGGATATC
GAGGGGCTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References