Detailed information of TA system TA125890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2590690..2591241
• Replicon: chromosome
• Accession: NZ_CP040517
• Organism: Luteithermobacter gelatinilyticus strain MEBiC09520

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FE788_RS11635
• Protein ID: WP_138380798.1
• Coordinates: 2590690..2590986 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FE788_RS11640
• Protein ID: WP_138380799.1
• Coordinates: 2590993..2591241 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE788_RS11615	2585923..2587056	+	1134	WP_138380794.1	glycine cleavage system aminomethyltransferase GcvT	-
FE788_RS11620	2587096..2587470	+	375	WP_138380795.1	glycine cleavage system protein GcvH	-
FE788_RS11625	2587512..2588858	+	1347	WP_138380796.1	aminomethyl-transferring glycine dehydrogenase subunit GcvPA	-
FE788_RS11630	2588855..2590432	+	1578	WP_138380797.1	aminomethyl-transferring glycine dehydrogenase subunit GcvPB	-
FE788_RS11635	2590690..2590986	-	297	WP_138380798.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FE788_RS11640	2590993..2591241	-	249	WP_138380799.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FE788_RS11645	2591364..2592227	-	864	WP_138380800.1	MipA/OmpV family protein	-
FE788_RS11650	2592431..2592859	+	429	WP_210413954.1	Rid family detoxifying hydrolase	-
FE788_RS11655	2592941..2594179	-	1239	WP_138380801.1	bifunctional alpha/beta hydrolase/OsmC family protein	-
FE788_RS11660	2594148..2595515	-	1368	WP_168190391.1	glycosyltransferase family 4 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-70)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11326.31 Da
• Isoelectric Point: 11.0123

>T125890 WP_138380798.1 NZ_CP040517:c2590986-2590690 [Luteithermobacter gelatinilyticus]
MAYDLAFLAPALKEWRVLDAPVRSQFKKKLAERLENPHVPSSRLFGSQKRYKIKLRAAGYRLVYEVSDREILVTVIAVGK
RERNQVYKIAAKRNIQGP

Nucleotide

• Length: 297 bp

>T125890 NZ_CP040517:c2590986-2590690 [Luteithermobacter gelatinilyticus]
ATGGCGTATGACTTGGCATTCTTGGCCCCGGCGTTAAAGGAGTGGCGGGTGCTGGATGCACCGGTGCGCAGTCAGTTCAA
GAAAAAACTCGCTGAGCGGCTCGAAAATCCGCATGTCCCGTCTTCGCGCCTGTTCGGCAGCCAGAAGCGGTATAAAATAA
AGTTAAGGGCTGCGGGGTACCGGCTGGTCTATGAAGTCAGTGACCGCGAAATCCTTGTGACGGTGATTGCGGTGGGTAAA
CGCGAACGCAATCAGGTCTATAAAATCGCCGCAAAGCGAAATATCCAAGGTCCTTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9163.63 Da
• Isoelectric Point: 4.5858

>AT125890 WP_138380799.1 NZ_CP040517:c2591241-2590993 [Luteithermobacter gelatinilyticus]
MTHVILADMTVSISDLKKNPMRVIEKGEGFPVAVLNRNRPAFYCVPAEAYEALMDKLEDMELNALADARQDAARVKVTLD
EL

Nucleotide

• Length: 249 bp

>AT125890 NZ_CP040517:c2591241-2590993 [Luteithermobacter gelatinilyticus]
ATGACCCATGTTATTCTGGCCGATATGACGGTGAGCATTTCTGATCTGAAAAAAAACCCCATGCGGGTGATTGAGAAGGG
CGAAGGTTTTCCCGTGGCGGTTCTCAATCGGAACCGGCCGGCCTTTTACTGTGTGCCAGCCGAGGCCTATGAGGCGTTGA
TGGACAAACTTGAGGATATGGAGCTTAATGCTCTGGCCGACGCCCGCCAAGATGCAGCGCGGGTGAAAGTCACCCTGGAT
GAGTTATAA