Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 922249..923816 Replicon chromosome
Accession NZ_CP040517
Organism Luteithermobacter gelatinilyticus strain MEBiC09520

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FE788_RS04185 Protein ID WP_138379463.1
Coordinates 922249..923562 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FE788_RS04190 Protein ID WP_138379464.1
Coordinates 923562..923816 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE788_RS04145 917346..917591 + 246 WP_138379456.1 tyrosine-type recombinase/integrase -
FE788_RS04150 917892..919163 + 1272 WP_138379457.1 site-specific integrase -
FE788_RS04155 919448..919885 + 438 WP_138379458.1 hypothetical protein -
FE788_RS04160 919986..920177 + 192 WP_138379459.1 AlpA family phage regulatory protein -
FE788_RS04170 920355..920900 + 546 WP_138379461.1 hypothetical protein -
FE788_RS04175 920911..921288 + 378 WP_138379462.1 helix-turn-helix domain-containing protein -
FE788_RS04180 921612..922171 - 560 Protein_816 transposase -
FE788_RS04185 922249..923562 - 1314 WP_138379463.1 type II toxin-antitoxin system HipA family toxin Toxin
FE788_RS04190 923562..923816 - 255 WP_138379464.1 helix-turn-helix domain-containing protein Antitoxin
FE788_RS04195 923960..924157 + 198 WP_138379465.1 hypothetical protein -
FE788_RS04200 924176..925789 + 1614 WP_138379466.1 type I restriction-modification system subunit M -
FE788_RS04205 925782..927131 + 1350 WP_138379467.1 restriction endonuclease subunit S -
FE788_RS04210 927128..928717 + 1590 WP_138379468.1 TIGR04141 family sporadically distributed protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 921890..922171 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-47)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48449.66 Da        Isoelectric Point: 7.5309

>T125889 WP_138379463.1 NZ_CP040517:c923562-922249 [Luteithermobacter gelatinilyticus]
MARRKRHAPLAVYLNSRLVGQLRKAASGAVDFQYDDSWLSWEDAFPISLSLPLREDRYIGAAVIAVFDNLLPDNPDIRRK
LAERARADGTDAFNLLSAIGRDCVGALQFLPEDIAPGPPGGIDARPVSDDEIAALLGDLGNSPLGIGADEEFRISLAGAQ
EKTALLHWKDQWHIPHGTTATTHIFKPEIGKRPDGIDLSLSVENEHLCMTLMNALGLPAAETAITRFGNRKVLVVKRFDR
LWTTDKRLLRLPQEDCCQALSVPPARKYESDGGPGLAGLIGLFTSSDTPLEDQRRIMKAAIVFWLLAATDGHAKNFSLFL
YPRSRFSLTPFYDVMSVQPLYDAKQLQQRQMKMAMAIGKSRHYLVHRIAPRHFLETAEACGMGKNIVQELFAELLDRSDK
AIDKTLAALPNGFPHGLTESIIGGYHRRLRQLEAIIT

Download         Length: 1314 bp

>T125889 NZ_CP040517:c923562-922249 [Luteithermobacter gelatinilyticus]
ATGGCCCGCCGCAAAAGACATGCCCCGCTTGCGGTTTATCTGAACAGCCGGTTGGTCGGCCAGCTGCGCAAGGCCGCGAG
CGGCGCCGTCGATTTCCAGTATGATGACAGCTGGCTGTCCTGGGAGGATGCTTTCCCGATCTCCCTCTCGCTGCCGCTGC
GCGAGGATCGCTATATCGGCGCGGCGGTGATCGCGGTGTTCGATAATCTGCTCCCGGATAATCCCGATATCCGCCGCAAG
CTTGCCGAACGCGCCCGGGCCGATGGGACCGATGCCTTCAACCTGCTGAGCGCAATCGGCCGCGACTGCGTCGGCGCCCT
GCAGTTCTTGCCCGAAGACATTGCCCCGGGACCGCCCGGCGGGATCGACGCAAGGCCCGTGAGTGACGATGAGATCGCCG
CGCTGCTAGGAGACCTTGGCAATAGTCCGCTCGGCATTGGCGCGGATGAAGAATTCCGGATTTCATTGGCGGGCGCGCAG
GAAAAAACCGCCCTGCTGCATTGGAAGGACCAGTGGCATATCCCGCACGGCACAACGGCGACCACCCACATCTTCAAACC
GGAGATCGGCAAGCGGCCGGACGGCATCGACCTTTCACTCTCGGTCGAGAACGAGCATCTGTGCATGACGCTGATGAATG
CGCTCGGCCTGCCGGCTGCCGAAACTGCAATCACGCGCTTTGGCAACAGGAAAGTGCTCGTCGTCAAGCGGTTCGACCGG
CTCTGGACCACGGATAAACGGCTGCTGCGCCTGCCGCAGGAAGATTGCTGCCAGGCGTTGTCGGTTCCGCCGGCCCGGAA
ATATGAAAGCGATGGTGGCCCGGGCCTGGCTGGGCTGATTGGCCTGTTCACCAGCAGCGATACGCCCCTTGAGGATCAGC
GGCGGATCATGAAGGCCGCGATTGTGTTCTGGTTGCTCGCCGCGACCGACGGTCACGCCAAGAATTTCAGCCTGTTCCTG
TACCCGCGCAGCCGGTTTTCTCTAACGCCGTTTTACGATGTCATGTCGGTCCAGCCGCTCTATGACGCGAAGCAGCTGCA
GCAACGTCAGATGAAAATGGCAATGGCCATCGGTAAAAGCCGGCATTACCTCGTGCATAGAATTGCTCCCCGGCACTTTC
TGGAAACGGCCGAAGCCTGCGGCATGGGCAAAAACATCGTCCAGGAGCTGTTCGCAGAGTTGCTGGATCGCAGCGACAAA
GCTATCGATAAAACGCTGGCCGCGCTGCCGAACGGTTTCCCACATGGCCTCACCGAGTCGATCATCGGCGGCTACCACCG
CCGCCTGCGCCAGCTGGAAGCGATCATCACCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9243.73 Da        Isoelectric Point: 10.5888

>AT125889 WP_138379464.1 NZ_CP040517:c923816-923562 [Luteithermobacter gelatinilyticus]
MTEQIARSEKQLGAILRRVRKQRGLTQSQLGEKIHLRQATISKLEDGAPATQLATVIAALAALDLELVVRPRSQAKPEDI
EGLF

Download         Length: 255 bp

>AT125889 NZ_CP040517:c923816-923562 [Luteithermobacter gelatinilyticus]
ATGACCGAACAGATTGCCAGATCAGAAAAACAGCTGGGCGCCATCCTGCGCCGGGTCCGCAAGCAACGGGGCCTGACGCA
ATCCCAGCTCGGCGAAAAAATCCATCTGCGCCAGGCGACCATTTCCAAGCTGGAGGACGGCGCCCCGGCCACGCAGCTTG
CCACGGTTATTGCCGCCCTGGCCGCGCTCGATCTGGAGCTTGTCGTCCGGCCGCGCAGCCAGGCCAAGCCAGAGGATATC
GAGGGGCTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References