Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 5065336..5065978 Replicon chromosome
Accession NZ_CP040515
Organism Bacillus paranthracis strain PR1

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag BCPR1_RS26175 Protein ID WP_000635963.1
Coordinates 5065336..5065686 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag BCPR1_RS26180 Protein ID WP_000004570.1
Coordinates 5065691..5065978 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCPR1_RS26160 5062273..5062731 - 459 WP_000344246.1 SprT family protein -
BCPR1_RS26165 5062927..5063043 + 117 WP_001143642.1 cortex morphogenetic protein CmpA -
BCPR1_RS26170 5063101..5065269 - 2169 WP_000426219.1 RNA-binding transcriptional accessory protein -
BCPR1_RS26175 5065336..5065686 - 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BCPR1_RS26180 5065691..5065978 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
BCPR1_RS26185 5066278..5067447 - 1170 WP_000390609.1 alanine racemase -
BCPR1_RS26190 5067565..5068515 - 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
BCPR1_RS26195 5068672..5069031 - 360 WP_000635037.1 holo-ACP synthase -
BCPR1_RS26200 5069124..5069696 + 573 WP_000906920.1 rhomboid family intramembrane serine protease -
BCPR1_RS26205 5069689..5070651 - 963 WP_138322550.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T125888 WP_000635963.1 NZ_CP040515:c5065686-5065336 [Bacillus paranthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T125888 NZ_CP040515:c5065686-5065336 [Bacillus paranthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT125888 WP_000004570.1 NZ_CP040515:c5065978-5065691 [Bacillus paranthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT125888 NZ_CP040515:c5065978-5065691 [Bacillus paranthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References