Detailed information of TA system TA125887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2917390..2918366
• Replicon: chromosome
• Accession: NZ_CP040515
• Organism: Bacillus paranthracis strain PR1

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: BCPR1_RS15280
• Protein ID: WP_138322606.1
• Coordinates: 2917629..2918366 (-)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: BCPR1_RS15275
• Protein ID: WP_000588712.1
• Coordinates: 2917390..2917515 (-)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCPR1_RS15260	2913434..2913904	+	471	WP_000771842.1	DUF5065 family protein	-
BCPR1_RS15265	2914489..2915958	-	1470	WP_070806032.1	beta-Ala-His dipeptidase	-
BCPR1_RS27720	2916101..2916277	-	177	WP_076855777.1	hypothetical protein	-
BCPR1_RS15270	2916835..2917116	+	282	WP_138321994.1	hypothetical protein	-
BCPR1_RS27725	2917153..2917314	-	162	WP_167495101.1	hypothetical protein	-
BCPR1_RS15275	2917390..2917515	-	126	WP_000588712.1	hypothetical protein	Antitoxin
BCPR1_RS15280	2917629..2918366	-	738	WP_138322606.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
BCPR1_RS15285	2918555..2919292	-	738	WP_000594146.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
BCPR1_RS15290	2919459..2919941	-	483	WP_000191902.1	MarR family winged helix-turn-helix transcriptional regulator	-
BCPR1_RS15295	2920048..2921733	+	1686	WP_138321995.1	alpha-keto acid decarboxylase family protein	-
BCPR1_RS15300	2921855..2922637	-	783	WP_138321996.1	class I SAM-dependent methyltransferase	-
BCPR1_RS15305	2922930..2923337	-	408	WP_087931797.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28457.12 Da
• Isoelectric Point: 7.3119

>T125887 WP_138322606.1 NZ_CP040515:c2918366-2917629 [Bacillus paranthracis]
VISNIRIGLFILAIFFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHMEEDYTKSLNAFLDSYGEKIGAKI
VVFEAEKELNTNFRGIRSQFSTIISLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T125887 NZ_CP040515:c2918366-2917629 [Bacillus paranthracis]
GTGATCTCTAACATTCGAATCGGTTTATTTATTTTAGCAATCTTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAGCGAATTAGAAAGACTTGGTATGGATTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTTGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTATTCGGTACGATGG
AATGGCATATGGAAGAAGACTATACAAAAAGTTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGAAAAAGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTTCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT125887 WP_000588712.1 NZ_CP040515:c2917515-2917390 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT125887 NZ_CP040515:c2917515-2917390 [Bacillus paranthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACTGATTTCTCTTTAATAAAAGGAGATAC
GTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A366GQT1