Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 601117..601753 Replicon chromosome
Accession NZ_CP040514
Organism Bacillus altitudinis strain GQYP101

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag BPGQ101_RS03065 Protein ID WP_003214169.1
Coordinates 601403..601753 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag BPGQ101_RS03060 Protein ID WP_003214273.1
Coordinates 601117..601398 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPGQ101_RS03040 597271..597876 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
BPGQ101_RS03045 597971..598336 + 366 WP_017366663.1 holo-ACP synthase -
BPGQ101_RS03050 598497..599513 + 1017 WP_138278136.1 outer membrane lipoprotein-sorting protein -
BPGQ101_RS03055 599641..600819 + 1179 WP_138278137.1 alanine racemase -
BPGQ101_RS03060 601117..601398 + 282 WP_003214273.1 hypothetical protein Antitoxin
BPGQ101_RS03065 601403..601753 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BPGQ101_RS03070 601868..602698 + 831 WP_017358395.1 STAS domain-containing protein -
BPGQ101_RS03075 602703..603071 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
BPGQ101_RS03080 603074..603475 + 402 WP_003214085.1 anti-sigma regulatory factor -
BPGQ101_RS03085 603486..604493 + 1008 WP_017358394.1 PP2C family protein-serine/threonine phosphatase -
BPGQ101_RS03090 604553..604882 + 330 WP_017358393.1 anti-sigma factor antagonist -
BPGQ101_RS03095 604879..605367 + 489 WP_041507147.1 anti-sigma B factor RsbW -
BPGQ101_RS03100 605333..606121 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
BPGQ101_RS03105 606121..606720 + 600 WP_024719202.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T125886 WP_003214169.1 NZ_CP040514:601403-601753 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T125886 NZ_CP040514:601403-601753 [Bacillus altitudinis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCGGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAAATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT125886 WP_003214273.1 NZ_CP040514:601117-601398 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT125886 NZ_CP040514:601117-601398 [Bacillus altitudinis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References