Detailed information of TA system TA125877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1140881..1141406
• Replicon: chromosome
• Accession: NZ_CP040511
• Organism: Acidithiobacillus ferrooxidans strain YNTRS-40

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B7J6U7
• Locus tag: FE661_RS05920
• Protein ID: WP_009564272.1
• Coordinates: 1141125..1141406 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B7J6U6
• Locus tag: FE661_RS05915
• Protein ID: WP_009564270.1
• Coordinates: 1140881..1141135 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE661_RS05875	1135928..1136599	-	672	WP_012536411.1	LysR family transcriptional regulator	-
FE661_RS05880	1136797..1137241	+	445	Protein_1156	SDR family oxidoreductase	-
FE661_RS05885	1137410..1138078	+	669	WP_009561118.1	cupin domain-containing protein	-
FE661_RS05890	1138075..1139238	+	1164	WP_012536412.1	FAD-dependent oxidoreductase	-
FE661_RS05895	1139235..1139324	+	90	Protein_1159	short-chain dehydrogenase	-
FE661_RS05900	1139296..1139581	+	286	Protein_1160	hypothetical protein	-
FE661_RS05905	1139812..1140147	+	336	WP_012536413.1	shufflon-specific DNA recombinase	-
FE661_RS05910	1140334..1140633	+	300	WP_009564269.1	YbjQ family protein	-
FE661_RS05915	1140881..1141135	+	255	WP_009564270.1	antitoxin	Antitoxin
FE661_RS05920	1141125..1141406	+	282	WP_009564272.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FE661_RS05930	1141949..1143172	-	1224	WP_012536416.1	class I SAM-dependent rRNA methyltransferase	-
FE661_RS05935	1143327..1144379	+	1053	WP_012536417.1	S-methyl-5-thioribose-1-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10757.61 Da
• Isoelectric Point: 10.6855

>T125877 WP_009564272.1 NZ_CP040511:1141125-1141406 [Acidithiobacillus ferrooxidans]
MPYELTFHPSALKEWQALDHSVRAPFKKKLAERLVHPRVPSAQLHGHPDRYKIKLRSIGYRLIYQVMETEVQVLVLAVGK
REGSVAYHKAKGR

Nucleotide

• Length: 282 bp

>T125877 NZ_CP040511:1141125-1141406 [Acidithiobacillus ferrooxidans]
ATGCCTTATGAGCTCACTTTCCATCCCTCCGCCCTCAAAGAATGGCAGGCCTTGGACCATAGCGTCCGTGCCCCATTCAA
AAAGAAACTGGCAGAACGCTTAGTGCACCCACGCGTCCCTTCCGCTCAACTGCATGGCCACCCGGATCGCTATAAGATCA
AACTCCGCAGCATAGGCTATCGCTTGATCTACCAAGTGATGGAAACGGAAGTCCAAGTGTTGGTCCTGGCGGTAGGCAAG
CGGGAAGGCTCTGTCGCCTATCACAAGGCCAAAGGACGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8832.16 Da
• Isoelectric Point: 4.6615

>AT125877 WP_009564270.1 NZ_CP040511:1140881-1141135 [Acidithiobacillus ferrooxidans]
MTHVILADVAASVSELKKNPMGTVAAGEGATVAILNRNEPAFYCVPAATYAALLEHLENLELNALAESRLKDGQTPIKVS
LDAL

Nucleotide

• Length: 255 bp

>AT125877 NZ_CP040511:1140881-1141135 [Acidithiobacillus ferrooxidans]
ATGACCCACGTCATTCTTGCCGATGTTGCTGCCAGTGTTTCCGAACTCAAAAAGAACCCTATGGGAACCGTGGCCGCAGG
AGAAGGGGCTACTGTGGCCATTCTCAACCGCAACGAACCGGCTTTTTACTGTGTCCCAGCCGCTACCTATGCTGCGCTTC
TGGAACATCTGGAAAATTTGGAGCTGAACGCTTTGGCGGAAAGCCGTCTGAAGGATGGCCAAACCCCGATCAAGGTGTCG
CTGGATGCCTTATGA

Structures

Toxin

• AlphaFold DB: B7J6U7

Antitoxin

• AlphaFold DB: B7J6U6