Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 501272..501912 Replicon chromosome
Accession NZ_CP040511
Organism Acidithiobacillus ferrooxidans strain YNTRS-40

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FE661_RS02695 Protein ID WP_009567232.1
Coordinates 501502..501912 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID B7J4M0
Locus tag FE661_RS02690 Protein ID WP_009567231.1
Coordinates 501272..501502 (+) Length 77 a.a.

Genomic Context

FE661_RS02675FE661_RS02680FE661_RS02685FE661_RS02690FE661_RS02695FE661_RS02700FE661_RS02705FE661_RS02710FE661_RS02715
Location: 497150..498280 (1131 bp)
Type: Others
Protein ID: WP_012536159.1
Location: 498280..499245 (966 bp)
Type: Others
Protein ID: WP_009567244.1
Location: 499246..501063 (1818 bp)
Type: Others
Protein ID: WP_012536160.1
Location: 501272..501502 (231 bp)
Type: Antitoxin
Protein ID: WP_009567231.1
Location: 501502..501912 (411 bp)
Type: Toxin
Protein ID: WP_009567232.1
Location: 502045..503143 (1099 bp)
Type: Others
Protein ID: WP_012606567.1
Location: 503180..504670 (1491 bp)
Type: Others
Protein ID: WP_009568984.1
Location: 504667..505911 (1245 bp)
Type: Others
Protein ID: WP_012536161.1
Location: 505904..506599 (696 bp)
Type: Others
Protein ID: WP_009566877.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FE661_RS02675497150..498280+1131WP_012536159.1threonine synthase-
FE661_RS02680498280..499245+966WP_009567244.1hypothetical protein-
FE661_RS02685499246..501063+1818WP_012536160.1single-stranded DNA exonuclease-
FE661_RS02690501272..501502+231WP_009567231.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
FE661_RS02695501502..501912+411WP_009567232.1type II toxin-antitoxin system VapC family toxinToxin
FE661_RS02700502045..503143+1099WP_012606567.1peptide chain release factor 2-
FE661_RS02705503180..504670+1491WP_009568984.1lysine--tRNA ligase-
FE661_RS02710504667..505911+1245WP_012536161.1lipoprotein-releasing ABC transporter permease subunit-
FE661_RS02715505904..506599+696WP_009566877.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15278.46 Da        Isoelectric Point: 7.3848

>T125876 WP_009567232.1 NZ_CP040511:501502-501912 [Acidithiobacillus ferrooxidans]
MTLRYLLDTNICIYIAKHHPPAVRERFVQHGADDLAMSVITLGELCWGAEKSQARDKALASIQRLQERIQVAPLTPQVGI
HYGQIRAALESGGRPIGNNDLWIAAHARAEGWIVVTNNEREFRRVEGLQVENWVTA

Download         Length: 411 bp

>T125876 NZ_CP040511:501502-501912 [Acidithiobacillus ferrooxidans]
ATGACCTTGCGTTATCTGCTGGATACCAATATCTGCATTTATATTGCCAAACACCATCCGCCCGCCGTGCGGGAGCGTTT
TGTACAACATGGTGCCGATGATCTGGCGATGTCGGTAATCACCTTGGGTGAATTGTGTTGGGGTGCGGAAAAAAGTCAGG
CGCGTGACAAAGCGTTGGCCAGCATACAGCGCCTGCAAGAACGTATTCAGGTGGCCCCCCTCACCCCTCAGGTCGGCATC
CACTATGGCCAGATCCGCGCGGCTCTGGAAAGCGGCGGGCGGCCCATTGGCAATAATGATCTGTGGATCGCCGCACACGC
CCGCGCCGAAGGCTGGATCGTAGTTACCAACAATGAACGAGAGTTCCGACGGGTGGAAGGATTGCAAGTGGAAAACTGGG
TAACGGCATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.76 Da        Isoelectric Point: 4.4217

>AT125876 WP_009567231.1 NZ_CP040511:501272-501502 [Acidithiobacillus ferrooxidans]
MAIARIFQSGNSQAVRLPKEFRFEVDQVEIFRRGNEIILREHPVDGTGVFDALADLPEDFMSDGRQDIPPQARENF

Download         Length: 231 bp

>AT125876 NZ_CP040511:501272-501502 [Acidithiobacillus ferrooxidans]
ATGGCCATCGCACGCATCTTCCAATCAGGCAACAGTCAGGCCGTACGGTTGCCCAAAGAATTCCGCTTTGAGGTGGATCA
GGTGGAAATCTTCCGCCGCGGGAATGAGATTATTCTGCGGGAGCATCCAGTGGATGGTACAGGCGTTTTTGATGCCCTGG
CCGACCTTCCCGAAGACTTCATGTCCGACGGACGCCAGGATATTCCACCCCAGGCAAGGGAAAACTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBB7J4M0

References