Detailed information of TA system TA125876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 501272..501912
• Replicon: chromosome
• Accession: NZ_CP040511
• Organism: Acidithiobacillus ferrooxidans strain YNTRS-40

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FE661_RS02695
• Protein ID: WP_009567232.1
• Coordinates: 501502..501912 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: B7J4M0
• Locus tag: FE661_RS02690
• Protein ID: WP_009567231.1
• Coordinates: 501272..501502 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE661_RS02675	497150..498280	+	1131	WP_012536159.1	threonine synthase	-
FE661_RS02680	498280..499245	+	966	WP_009567244.1	hypothetical protein	-
FE661_RS02685	499246..501063	+	1818	WP_012536160.1	single-stranded DNA exonuclease	-
FE661_RS02690	501272..501502	+	231	WP_009567231.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FE661_RS02695	501502..501912	+	411	WP_009567232.1	type II toxin-antitoxin system VapC family toxin	Toxin
FE661_RS02700	502045..503143	+	1099	WP_012606567.1	peptide chain release factor 2	-
FE661_RS02705	503180..504670	+	1491	WP_009568984.1	lysine--tRNA ligase	-
FE661_RS02710	504667..505911	+	1245	WP_012536161.1	lipoprotein-releasing ABC transporter permease subunit	-
FE661_RS02715	505904..506599	+	696	WP_009566877.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-127)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15278.46 Da
• Isoelectric Point: 7.3848

>T125876 WP_009567232.1 NZ_CP040511:501502-501912 [Acidithiobacillus ferrooxidans]
MTLRYLLDTNICIYIAKHHPPAVRERFVQHGADDLAMSVITLGELCWGAEKSQARDKALASIQRLQERIQVAPLTPQVGI
HYGQIRAALESGGRPIGNNDLWIAAHARAEGWIVVTNNEREFRRVEGLQVENWVTA

Nucleotide

• Length: 411 bp

>T125876 NZ_CP040511:501502-501912 [Acidithiobacillus ferrooxidans]
ATGACCTTGCGTTATCTGCTGGATACCAATATCTGCATTTATATTGCCAAACACCATCCGCCCGCCGTGCGGGAGCGTTT
TGTACAACATGGTGCCGATGATCTGGCGATGTCGGTAATCACCTTGGGTGAATTGTGTTGGGGTGCGGAAAAAAGTCAGG
CGCGTGACAAAGCGTTGGCCAGCATACAGCGCCTGCAAGAACGTATTCAGGTGGCCCCCCTCACCCCTCAGGTCGGCATC
CACTATGGCCAGATCCGCGCGGCTCTGGAAAGCGGCGGGCGGCCCATTGGCAATAATGATCTGTGGATCGCCGCACACGC
CCGCGCCGAAGGCTGGATCGTAGTTACCAACAATGAACGAGAGTTCCGACGGGTGGAAGGATTGCAAGTGGAAAACTGGG
TAACGGCATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8704.76 Da
• Isoelectric Point: 4.4217

>AT125876 WP_009567231.1 NZ_CP040511:501272-501502 [Acidithiobacillus ferrooxidans]
MAIARIFQSGNSQAVRLPKEFRFEVDQVEIFRRGNEIILREHPVDGTGVFDALADLPEDFMSDGRQDIPPQARENF

Nucleotide

• Length: 231 bp

>AT125876 NZ_CP040511:501272-501502 [Acidithiobacillus ferrooxidans]
ATGGCCATCGCACGCATCTTCCAATCAGGCAACAGTCAGGCCGTACGGTTGCCCAAAGAATTCCGCTTTGAGGTGGATCA
GGTGGAAATCTTCCGCCGCGGGAATGAGATTATTCTGCGGGAGCATCCAGTGGATGGTACAGGCGTTTTTGATGCCCTGG
CCGACCTTCCCGAAGACTTCATGTCCGACGGACGCCAGGATATTCCACCCCAGGCAAGGGAAAACTTTTGA

Structures

Antitoxin

• AlphaFold DB: B7J4M0