Detailed information of TA system TA125873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 5138922..5139453
• Replicon: chromosome
• Accession: NZ_CP040506
• Organism: Hungatella hathewayi WAL-18680

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G5ID78
• Locus tag: FFD75_RS23345
• Protein ID: WP_006779435.1
• Coordinates: 5139181..5139453 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G5ID77
• Locus tag: FFD75_RS23340
• Protein ID: WP_006779434.1
• Coordinates: 5138922..5139188 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFD75_RS23320	5134735..5136162	+	1428	WP_034858082.1	rhamnulokinase	-
FFD75_RS23325	5136162..5136476	+	315	WP_006779431.1	L-rhamnose mutarotase	-
FFD75_RS23330	5136525..5137772	+	1248	WP_006779432.1	L-rhamnose isomerase	-
FFD75_RS23335	5137836..5138663	+	828	WP_006779433.1	rhamnulose-1-phosphate aldolase	-
FFD75_RS23340	5138922..5139188	+	267	WP_006779434.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FFD75_RS23345	5139181..5139453	+	273	WP_006779435.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FFD75_RS23350	5139640..5140740	+	1101	WP_006779436.1	aldo/keto reductase	-
FFD75_RS23355	5140938..5141921	+	984	WP_006779437.1	helix-turn-helix domain-containing protein	-
FFD75_RS23360	5142116..5142826	+	711	WP_034858930.1	response regulator transcription factor	-
FFD75_RS23365	5142820..5143989	+	1170	WP_006779439.1	HAMP domain-containing histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-79)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10741.34 Da
• Isoelectric Point: 7.2400

>T125873 WP_006779435.1 NZ_CP040506:5139181-5139453 [Hungatella hathewayi WAL-18680]
MLEIRYSTKFKKDYKTIIKRGYNPQFLQDVLEILCNEQSLPPKFKDHNLSGNYEGYRECHITPDWLLIYKIEQETLTLIL
TRTGSHSDLF

Nucleotide

• Length: 273 bp

>T125873 NZ_CP040506:5139181-5139453 [Hungatella hathewayi WAL-18680]
ATGCTTGAGATAAGATATTCTACTAAATTTAAAAAGGATTATAAGACTATTATCAAGCGTGGTTACAATCCGCAATTTTT
ACAAGACGTTTTAGAAATTTTATGTAATGAACAGTCATTGCCACCTAAGTTCAAAGACCATAATTTGTCAGGTAATTACG
AAGGATATAGGGAATGTCACATAACACCGGATTGGCTGCTGATTTATAAGATTGAGCAGGAAACATTAACATTAATATTA
ACGCGGACAGGAAGTCATAGCGATTTATTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10008.38 Da
• Isoelectric Point: 4.4848

>AT125873 WP_006779434.1 NZ_CP040506:5138922-5139188 [Hungatella hathewayi WAL-18680]
MAQTNINIRMDDNLKQQFDWLCNELGLNMTTAINIFAKTMVRQQKIPFEVGLDIPNSETLAAIDDVNHGRNLSKTFHSVT
ELMEDLNA

Nucleotide

• Length: 267 bp

>AT125873 NZ_CP040506:5138922-5139188 [Hungatella hathewayi WAL-18680]
ATGGCTCAAACAAACATTAATATTCGTATGGATGATAATTTAAAACAGCAATTTGACTGGCTTTGCAATGAACTTGGCTT
AAATATGACCACAGCTATTAATATTTTTGCTAAAACCATGGTGCGTCAACAAAAAATACCTTTTGAAGTTGGTCTCGATA
TCCCCAATTCAGAAACTCTTGCGGCGATTGATGATGTAAATCATGGACGTAACCTTAGCAAGACGTTCCACAGCGTAACA
GAGTTGATGGAGGATTTAAATGCTTGA

Structures

Toxin

• AlphaFold DB: G5ID78

Antitoxin

• AlphaFold DB: G5ID77