Detailed information of TA system TA125871

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 4476232..4476921
• Replicon: chromosome
• Accession: NZ_CP040506
• Organism: Hungatella hathewayi WAL-18680

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FFD75_RS20410
• Protein ID: WP_080568780.1
• Coordinates: 4476232..4476420 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G5IBE4
• Locus tag: FFD75_RS20415
• Protein ID: WP_006778851.1
• Coordinates: 4476469..4476921 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFD75_RS20385	4472363..4473271	+	909	WP_006778846.1	sugar ABC transporter permease	-
FFD75_RS20390	4473284..4474165	+	882	WP_006778847.1	carbohydrate ABC transporter permease	-
FFD75_RS20395	4474218..4474940	+	723	WP_006778848.1	glycerophosphodiester phosphodiesterase	-
FFD75_RS20400	4475286..4475672	+	387	WP_198138515.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FFD75_RS20405	4475659..4475997	+	339	WP_006778850.1	helix-turn-helix transcriptional regulator	-
FFD75_RS20410	4476232..4476420	+	189	WP_080568780.1	type II toxin-antitoxin system HicA family toxin	Toxin
FFD75_RS20415	4476469..4476921	+	453	WP_006778851.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FFD75_RS20420	4477182..4477625	+	444	WP_006778852.1	hypothetical protein	-
FFD75_RS20425	4477819..4479150	+	1332	WP_006778853.1	sugar ABC transporter substrate-binding protein	-
FFD75_RS20430	4479214..4480077	+	864	WP_198138522.1	sugar ABC transporter permease	-
FFD75_RS20435	4480085..4480924	+	840	WP_006778855.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-98)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7136.46 Da
• Isoelectric Point: 10.4060

>T125871 WP_080568780.1 NZ_CP040506:4476232-4476420 [Hungatella hathewayi WAL-18680]
MPMKPKELERMILADGWKYKSQEGSHRYYIHPVKPGKVTIPFHGKTLPIGTEYAILKQAGLR

Nucleotide

• Length: 189 bp

>T125871 NZ_CP040506:4476232-4476420 [Hungatella hathewayi WAL-18680]
ATGCCAATGAAGCCGAAAGAGTTGGAGAGAATGATTCTTGCAGATGGCTGGAAATATAAATCACAGGAGGGTTCTCACAG
GTATTACATACATCCCGTTAAACCTGGGAAGGTTACAATCCCGTTTCATGGAAAGACATTGCCAATAGGAACGGAATATG
CAATCTTGAAGCAGGCAGGTTTAAGATAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16422.91 Da
• Isoelectric Point: 4.6566

>AT125871 WP_006778851.1 NZ_CP040506:4476469-4476921 [Hungatella hathewayi WAL-18680]
MLSAYPACFLKEENGYSVIFPDLNYLATCGETLEEALAMAVDCLAGYLYMSEMDRDVVPPPSEMGAISLSGICKELGVED
GEGFVNLVTVNVSEYAKNHFEKSVKKTLTIPAWLNTAALKKNINFSQVLQEALKEKLATGKADGRYGKRL

Nucleotide

• Length: 453 bp

>AT125871 NZ_CP040506:4476469-4476921 [Hungatella hathewayi WAL-18680]
ATGTTGTCTGCATATCCTGCGTGTTTTTTGAAAGAGGAGAATGGTTACTCGGTTATTTTCCCGGATTTGAATTATCTGGC
GACCTGTGGGGAAACGTTGGAAGAGGCACTGGCCATGGCGGTCGACTGCCTGGCCGGGTATCTGTATATGAGCGAAATGG
ATAGGGATGTGGTACCGCCACCTTCTGAGATGGGGGCTATCAGTTTGTCTGGAATTTGCAAGGAATTGGGTGTTGAGGAT
GGGGAAGGATTTGTAAATTTGGTTACGGTAAATGTGTCGGAGTATGCAAAGAATCATTTTGAGAAATCAGTGAAAAAGAC
ATTGACGATACCTGCATGGCTGAATACGGCGGCGTTGAAGAAGAATATTAATTTTTCGCAGGTATTACAGGAAGCATTGA
AAGAAAAGCTGGCTACTGGAAAGGCGGATGGGCGTTATGGGAAGAGACTTTGA

Structures

Antitoxin

• AlphaFold DB: G5IBE4