Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1047800..1048454 Replicon chromosome
Accession NZ_CP040456
Organism Escherichia coli strain UPEC132

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag FE252_RS06760 Protein ID WP_000244781.1
Coordinates 1048047..1048454 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FE252_RS06755 Protein ID WP_000354046.1
Coordinates 1047800..1048066 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE252_RS06735 1043888..1045321 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
FE252_RS06740 1045366..1045677 + 312 WP_001182948.1 N(4)-acetylcytidine aminohydrolase -
FE252_RS06745 1045841..1046500 + 660 WP_000250274.1 hemolysin III family protein -
FE252_RS06750 1046577..1047557 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
FE252_RS06755 1047800..1048066 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FE252_RS06760 1048047..1048454 + 408 WP_000244781.1 protein YgfX Toxin
FE252_RS06765 1048494..1049015 - 522 WP_001055874.1 flavodoxin FldB -
FE252_RS06770 1049127..1050023 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FE252_RS06775 1050048..1050758 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FE252_RS06780 1050764..1052497 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T125841 WP_000244781.1 NZ_CP040456:1048047-1048454 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T125841 NZ_CP040456:1048047-1048454 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT125841 WP_000354046.1 NZ_CP040456:1047800-1048066 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT125841 NZ_CP040456:1047800-1048066 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References