Detailed information of TA system TA125837

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 44711..45512
• Replicon: chromosome
• Accession: NZ_CP040456
• Organism: Escherichia coli strain UPEC132

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FE252_RS01745
• Protein ID: WP_112036162.1
• Coordinates: 44711..45088 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MN76
• Locus tag: FE252_RS01750
• Protein ID: WP_015953067.1
• Coordinates: 45135..45512 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE252_RS01710	40085..40903	+	819	WP_000779409.1	lipoprotein NlpA	-
FE252_RS01715	40907..41830	-	924	WP_001445306.1	carboxylate/amino acid/amine transporter	-
FE252_RS01720	41997..42494	-	498	WP_000509810.1	hypothetical protein	-
FE252_RS01730	43087..43932	-	846	Protein_43	DUF4942 domain-containing protein	-
FE252_RS01735	44017..44214	-	198	WP_000839243.1	DUF957 domain-containing protein	-
FE252_RS01740	44226..44714	-	489	WP_000761714.1	hypothetical protein	-
FE252_RS01745	44711..45088	-	378	WP_112036162.1	TA system toxin CbtA family protein	Toxin
FE252_RS01750	45135..45512	-	378	WP_015953067.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
FE252_RS01755	45591..45812	-	222	WP_000692312.1	DUF987 domain-containing protein	-
FE252_RS01760	45881..46357	-	477	WP_001186756.1	RadC family protein	-
FE252_RS01765	46372..46857	-	486	WP_000860054.1	antirestriction protein	-
FE252_RS01770	46948..47766	-	819	WP_001175142.1	DUF945 domain-containing protein	-
FE252_RS01775	47856..48089	-	234	WP_001278280.1	DUF905 family protein	-
FE252_RS01780	48095..48772	-	678	WP_001097307.1	hypothetical protein	-
FE252_RS01785	48920..49600	-	681	WP_001282927.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13988.87 Da
• Isoelectric Point: 6.8603

>T125837 WP_112036162.1 NZ_CP040456:c45088-44711 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRTRRATGLMTRNNYRMVNNITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T125837 NZ_CP040456:c45088-44711 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGACTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13766.60 Da
• Isoelectric Point: 6.2021

>AT125837 WP_015953067.1 NZ_CP040456:c45512-45135 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Nucleotide

• Length: 378 bp

>AT125837 NZ_CP040456:c45512-45135 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A5Z3CIS0