Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3718622..3720195 Replicon chromosome
Accession NZ_CP040449
Organism Aeromonas simiae strain A6

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FE240_RS17735 Protein ID WP_193002807.1
Coordinates 3718876..3720195 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FE240_RS17730 Protein ID WP_101323164.1
Coordinates 3718622..3718876 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE240_RS17705 3714956..3715687 + 732 WP_193004597.1 M48 family metallopeptidase -
FE240_RS17710 3716199..3716522 + 324 WP_193002804.1 hypothetical protein -
FE240_RS17715 3716519..3717136 - 618 WP_193002805.1 recombinase family protein -
FE240_RS17720 3717582..3718031 + 450 WP_193002806.1 nucleotidyltransferase domain-containing protein -
FE240_RS17725 3718024..3718452 + 429 WP_118882200.1 DUF86 domain-containing protein -
FE240_RS17730 3718622..3718876 + 255 WP_101323164.1 helix-turn-helix domain-containing protein Antitoxin
FE240_RS17735 3718876..3720195 + 1320 WP_193002807.1 type II toxin-antitoxin system HipA family toxin Toxin
FE240_RS17740 3720600..3722576 - 1977 WP_193002808.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
FE240_RS17745 3722573..3723436 - 864 WP_193002809.1 ABC transporter substrate-binding protein -
FE240_RS17750 3723433..3724197 - 765 WP_193002810.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ampH - 3680030..3803048 123018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49525.58 Da        Isoelectric Point: 6.5054

>T125827 WP_193002807.1 NZ_CP040449:3718876-3720195 [Aeromonas simiae]
MANLAVYMNGYRVGTFTKATSGAHQFQYHESWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNMEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNTTPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADSSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASIKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERITQQLPADFPDAISSTILEGLKARSARLLKGWD

Download         Length: 1320 bp

>T125827 NZ_CP040449:3718876-3720195 [Aeromonas simiae]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAGCTACCAGCGGCGCCCATCAATTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATTTCACTCTCCATGCCATTGCGCCATCAGCCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGATAACCTGCTGCCAGATAATATGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAACAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCC
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAACACAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATAGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTTGCGGCCACCGATGGCCATGCAAAGAACTTCTCAGTCTTTATT
GAACCGGAAGGACGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCATCAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGCC
ATTTTTTCCAAACGGCAAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCATTACCCAGCAATTGCCAGCAGACTTCCCCGATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGCTAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9323.64 Da        Isoelectric Point: 7.9834

>AT125827 WP_101323164.1 NZ_CP040449:3718622-3718876 [Aeromonas simiae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPTSGW
KEEW

Download         Length: 255 bp

>AT125827 NZ_CP040449:3718622-3718876 [Aeromonas simiae]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAAAAAGTAGGGATTAGGCAAGACACAGTCTCCAGCTTCGAACTCAACCCTGAGTCCACCAAGCTAGAGACCCTGT
TCAAGATCCTCGCGGCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGATAGTCCGACATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References