Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4571552..4572188 Replicon chromosome
Accession NZ_CP040443
Organism Escherichia sp. E4742

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FEM44_RS22275 Protein ID WP_135522763.1
Coordinates 4571552..4571728 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FEM44_RS22280 Protein ID WP_135522856.1
Coordinates 4571772..4572188 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEM44_RS22255 4567172..4568383 - 1212 WP_135522765.1 BenE family transporter YdcO -
FEM44_RS22260 4568436..4568972 + 537 WP_130260852.1 XRE family transcriptional regulator -
FEM44_RS22265 4569045..4571006 + 1962 WP_135522764.1 23S rRNA 5-hydroxycytidine C2501 synthase -
FEM44_RS22270 4571100..4571330 - 231 WP_130219296.1 YncJ family protein -
FEM44_RS22275 4571552..4571728 + 177 WP_135522763.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
FEM44_RS22280 4571772..4572188 + 417 WP_135522856.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
FEM44_RS22285 4572268..4573677 + 1410 WP_135522762.1 PLP-dependent aminotransferase family protein -
FEM44_RS22290 4573919..4575064 + 1146 WP_130222684.1 ABC transporter substrate-binding protein -
FEM44_RS22295 4575082..4576095 + 1014 WP_130222682.1 ABC transporter ATP-binding protein -
FEM44_RS22300 4576096..4577037 + 942 WP_135522626.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6750.84 Da        Isoelectric Point: 11.5666

>T125820 WP_135522763.1 NZ_CP040443:4571552-4571728 [Escherichia sp. E4742]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLI

Download         Length: 177 bp

>T125820 NZ_CP040443:4571552-4571728 [Escherichia sp. E4742]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAGGGGCGACGTAGTGTCATGCCGCGTCACCCCAGTGACGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTAATTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.56 Da        Isoelectric Point: 4.4787

>AT125820 WP_135522856.1 NZ_CP040443:4571772-4572188 [Escherichia sp. E4742]
MRYPVTLTPAPEGGYVVSFVDIPEALTQGETVVEAMEAAKDALLTAFDFYFEDNELIPLPSPLNNNDHFIEVPLSVASKV
LLLNAFLQSDITQQELARRIGKPRQEVTRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT125820 NZ_CP040443:4571772-4572188 [Escherichia sp. E4742]
ATGCGTTATCCCGTCACTCTTACACCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTAAC
GCAGGGAGAAACTGTTGTTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTAATCCCGTTGCCTTCGCCATTAAATAACAACGATCACTTTATTGAAGTGCCTTTAAGTGTCGCTTCTAAGGTA
TTGCTGTTAAATGCTTTTTTGCAGTCAGATATCACCCAGCAAGAGCTGGCGAGGCGGATTGGTAAACCCAGGCAGGAGGT
CACTCGCTTGTTTGATTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAAGCCCTGGGCAAAGAGTTAT
CGCTGGTAATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References