Detailed information of TA system TA125809

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1178123..1178958
• Replicon: chromosome
• Accession: NZ_CP040443
• Organism: Escherichia sp. E4742

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FEM44_RS05680
• Protein ID: WP_001094446.1
• Coordinates: 1178581..1178958 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FEM44_RS05675
• Protein ID: WP_135524059.1
• Coordinates: 1178123..1178491 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEM44_RS05635	1173255..1174139	+	885	WP_135523317.1	50S ribosome-binding GTPase	-
FEM44_RS05640	1174258..1174935	+	678	WP_135523318.1	hypothetical protein	-
FEM44_RS05645	1174941..1175174	+	234	WP_001278282.1	DUF905 family protein	-
FEM44_RS05650	1175264..1176082	+	819	WP_135523319.1	DUF945 domain-containing protein	-
FEM44_RS05655	1176174..1176659	+	486	WP_135523320.1	antirestriction protein	-
FEM44_RS05660	1176675..1177151	+	477	WP_001186745.1	RadC family protein	-
FEM44_RS05665	1177220..1177441	+	222	WP_000692303.1	DUF987 domain-containing protein	-
FEM44_RS05670	1177460..1178107	+	648	WP_135524060.1	antitoxin of toxin-antitoxin stability system	-
FEM44_RS05675	1178123..1178491	+	369	WP_135524059.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FEM44_RS05680	1178581..1178958	+	378	WP_001094446.1	TA system toxin CbtA family protein	Toxin
FEM44_RS05685	1178955..1179104	+	150	Protein_1081	hypothetical protein	-
FEM44_RS05690	1179180..1179377	+	198	WP_087891818.1	DUF957 domain-containing protein	-
FEM44_RS05695	1179462..1180307	+	846	WP_135524058.1	DUF4942 domain-containing protein	-
FEM44_RS05700	1180378..1181913	+	1536	WP_000492893.1	EAL domain-containing protein	-
FEM44_RS05705	1182175..1183578	-	1404	WP_135524057.1	type VI secretion system ImpA and VasL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14165.05 Da
• Isoelectric Point: 6.8522

>T125809 WP_001094446.1 NZ_CP040443:1178581-1178958 [Escherichia sp. E4742]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T125809 NZ_CP040443:1178581-1178958 [Escherichia sp. E4742]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13836.58 Da
• Isoelectric Point: 6.1191

>AT125809 WP_135524059.1 NZ_CP040443:1178123-1178491 [Escherichia sp. E4742]
VSDKLHETNYPDDHNDRLWWGLPCSVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPHHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMRN

Nucleotide

• Length: 369 bp

>AT125809 NZ_CP040443:1178123-1178491 [Escherichia sp. E4742]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTCCCCTGCTCCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCACCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAGAAATTAA