Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 492859..493484 Replicon chromosome
Accession NZ_CP040443
Organism Escherichia sp. E4742

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FEM44_RS02400 Protein ID WP_135521578.1
Coordinates 492859..493257 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FEM44_RS02405 Protein ID WP_000450525.1
Coordinates 493257..493484 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEM44_RS02380 488719..488919 + 201 WP_000383836.1 YpfN family protein -
FEM44_RS02385 489047..489745 - 699 WP_135521584.1 esterase -
FEM44_RS02390 489819..491834 - 2016 WP_135521582.1 tRNA cytosine(34) acetyltransferase TmcA -
FEM44_RS02395 491849..492712 - 864 WP_135521580.1 neutral zinc metallopeptidase -
FEM44_RS02400 492859..493257 - 399 WP_135521578.1 tRNA(fMet)-specific endonuclease VapC Toxin
FEM44_RS02405 493257..493484 - 228 WP_000450525.1 toxin-antitoxin system antitoxin VapB Antitoxin
FEM44_RS02410 493638..494351 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
FEM44_RS02415 494563..495597 - 1035 WP_130207447.1 outer membrane protein assembly factor BamC -
FEM44_RS02420 495614..496492 - 879 WP_135521576.1 4-hydroxy-tetrahydrodipicolinate synthase -
FEM44_RS02425 496639..497211 + 573 WP_130207451.1 glycine cleavage system transcriptional repressor -
FEM44_RS02430 497211..497681 + 471 WP_130207453.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14940.23 Da        Isoelectric Point: 7.8882

>T125807 WP_135521578.1 NZ_CP040443:c493257-492859 [Escherichia sp. E4742]
MLKFMLDTNICIFTIKNKPVHVRDRFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELAWQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T125807 NZ_CP040443:c493257-492859 [Escherichia sp. E4742]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGGGATCGCTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTAGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGAGCCGAGCTTGCCTGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTAGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.66 Da        Isoelectric Point: 4.3867

>AT125807 WP_000450525.1 NZ_CP040443:c493484-493257 [Escherichia sp. E4742]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPVGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT125807 NZ_CP040443:c493484-493257 [Escherichia sp. E4742]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCTGTCAGATTACCTAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATTACTCCCGTTGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATTCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References