Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 305505..306153 Replicon chromosome
Accession NZ_CP040440
Organism Stenotrophomonas maltophilia strain ICU331

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FEO84_RS01430 Protein ID WP_154344320.1
Coordinates 305505..305792 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag FEO84_RS01435 Protein ID WP_012478871.1
Coordinates 305851..306153 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEO84_RS01400 300765..301733 + 969 WP_012478821.1 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor -
FEO84_RS01405 301730..302461 + 732 WP_005407698.1 type III pantothenate kinase -
FEO84_RS01410 302471..303319 + 849 WP_012478822.1 SPOR domain-containing protein -
FEO84_RS01420 303520..304644 - 1125 WP_012478868.1 hypothetical protein -
FEO84_RS01425 304672..305271 - 600 WP_012478869.1 hypothetical protein -
FEO84_RS01430 305505..305792 + 288 WP_154344320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEO84_RS01435 305851..306153 + 303 WP_012478871.1 putative addiction module antidote protein Antitoxin
FEO84_RS01440 306211..306534 - 324 WP_012478872.1 hypothetical protein -
FEO84_RS01445 306614..307021 - 408 WP_044569408.1 hypothetical protein -
FEO84_RS01450 307615..308385 + 771 WP_012478874.1 DUF3011 domain-containing protein -
FEO84_RS01455 308445..309389 + 945 WP_012478875.1 ankyrin repeat domain-containing protein -
FEO84_RS01460 309494..310414 + 921 WP_005407709.1 arginase -
FEO84_RS01465 310575..310712 + 138 WP_005407710.1 entericidin A/B family lipoprotein -
FEO84_RS01470 310920..311141 + 222 WP_004153772.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10901.56 Da        Isoelectric Point: 11.1307

>T125803 WP_154344320.1 NZ_CP040440:305505-305792 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPRDHRYLGDGISELRIDAGPGYRLYYTQRGRQLLILLVGGDKSS
QQRDIEKAREIARAL

Download         Length: 288 bp

>T125803 NZ_CP040440:305505-305792 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCGCGTGATCACCGCTATCTGGGGGACGGTATTTCCGAACTGCGTATCGATG
CAGGGCCGGGCTACCGCCTGTACTACACCCAGCGCGGCAGGCAGTTGCTGATTCTTTTGGTCGGAGGTGACAAAAGCTCA
CAGCAACGCGATATCGAAAAGGCCAGGGAGATTGCACGTGCCCTGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10738.32 Da        Isoelectric Point: 8.0343

>AT125803 WP_012478871.1 NZ_CP040440:305851-306153 [Stenotrophomonas maltophilia]
MATKKKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Download         Length: 303 bp

>AT125803 NZ_CP040440:305851-306153 [Stenotrophomonas maltophilia]
ATGGCCACTAAGAAAAAAGTCGAACTCAAATCATTTGATGTGGCCGAACACCTTCGGACACCCGAAGAAATGGCAGCCTA
TCTCGACGCCTGCATCGAGGAAAGCGACGGCGATTCCGCGTTCATCGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAGG
GTATGAGCAAGGTTGCGCGCGCGGCGGGCCTGTCGCGCGAGAGTCTTTACCGCGCACTGTCCGGCGAACGCAGCCCCGAT
TTCGCCACCATCCTGAAGGTGACCCGTGCCTTGGGTGTGCGCCTGCATGCCAGTGCCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References